P1739 - Trends of Necrotizing Pancreatitis and Septic Shock Among Alcoholic vs Non-Alcoholic Pancreatitis: A Nationwide Inpatient Analysis

Manasa Ginjupalli, MBBS, MD¹, Vikash Kumar, MD², Jayalekshmi Jayakumar, MBBS, MD³, Sweta Lohani, MBBS, MD⁴, Anuj R. Sharma, MBBS⁴, Hamsika Moparty, MD³, Naresh Kumar, MD³, Suryanarayana Reddy Challa, MD⁵, Vijay Reddy Gayam, MD^6
1The Brooklyn Hospital Center, New York, NY; ²Creighton University School of Medicine, Brooklyn, NY; ³The Brooklyn Hospital Center, Brooklyn, NY; ⁴Brooklyn Hospital Center, Brooklyn, NY; ⁵NYU Langone Health, Hempstead, NY; ⁶University of Texas Southwestern Medical Center, Dallas, TX

Introduction: Pancreatitis poses significant clinical challenges due to its association with various complications, including necrotizing pancreatitis and sepsis. Patients with these complications have heightened mortality and require early recognition and management to prevent mortality. Alcohol abuse, being the single most important risk factor for pancreatitis, has limited available data regarding its effect on complications. We aimed to analyze the trends of necrotizing pancreatitis and sepsis in hospitalized adults with acute pancreatitis with and without alcohol abuse.

Methods: A retrospective analysis was performed on the National Inpatient Sample database 2016- 2020 and ICD-10 codes were used to identify hospitalized adults with diagnosis of pancreatitis and divided into two cohorts of Alcoholic pancreatitis and non alcoholic pancreatitis. Trends of Inpatient mortality, necrotizing pancreatitis and septic shock in hospitalized patients among these cohorts were analyzed. Categorical variables were compared using chi square and continuous variables were compared using t test.

Results: Over the period from 2016 to 2020, a reported population of 481,134 cases were diagnosed with alcoholic pancreatitis whereas non-alcoholic pancreatitis affected approximately 147 million individuals. Alcoholic pancreatitis has shown an upward trend from 88,799 to 104,690 cases whereas non-alcoholic pancreatitis exhibited a downtrend during the same period declining from 29.8 million to 27.3 million cases. Alcoholic pancreatitis showed a relatively stable inpatient mortality rate, starting at 1.01% in 2016 and increasing to 1.41% by 2020. In contrast, non-alcoholic pancreatitis consistently exhibited higher mortality rates, ranging from 2.19% to 3.20% over the same period. The incidence of necrotizing pancreatitis notably increased in alcoholic pancreatitis (1.63% to 8.05%), whereas rates remained very low in non-alcoholic cases (0.000033% to 0.00024%). Septic shock varied similarly in both groups (alcoholic: 2.57% to 3.38%, non-alcoholic: 3.03% to 4.50%) [Table 1]

Discussion: The rising rates of necrotizing pancreatitis and septic shock in alcoholic pancreatitis highlight the urgent need for targeted prevention and improved management, including early detection and intervention. Despite the significant burden of pancreatitis, this study offers insights into current trends and challenges. Ongoing research, education, and clinical efforts are essential to mitigate the impact of this complex condition on global health.


Disclosures:


Manasa Ginjupalli, MBBS, MD¹, Vikash Kumar, MD², Jayalekshmi Jayakumar, MBBS, MD³, Sweta Lohani, MBBS, MD⁴, Anuj R. Sharma, MBBS⁴, Hamsika Moparty, MD³, Naresh Kumar, MD³, Suryanarayana Reddy Challa, MD⁵, Vijay Reddy Gayam, MD⁶. P1739 - Trends of Necrotizing Pancreatitis and Septic Shock Among Alcoholic vs Non-Alcoholic Pancreatitis: A Nationwide Inpatient Analysis, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.