P1747 - Age Standardized Incidence and Mortality Rates of Pancreatic Cancer in the United States From 2010-2019: Analysis From the Global Burden of Disease Database

Ooreoluwa Fasola, MD¹, Godfrey Tabowei, MD^2
1Texas Tech University Health Sciences Center - Permian Basin, Odessa, TX; ²Texas Tech University Health Sciences Center, Odessa, TX

Introduction: Pancreatic cancer is one of the top causes of cancer-related deaths in the United States. There is a paucity of data regarding the impact of pancreatic cancer at the state level in the US. The aim of this study was to analyze the trends of age-standardized incidence and mortality rates of pancreatic cancer in different states of the United States.

Methods: Using the Global Burden of Disease data, we analyzed the incidence and mortality of pancreatic cancer at the state level in the United States between 2010 – 2019. We computed the annual percentage change in age-standardized incidence and mortality rates over this timeframe.


Results: In 2019, there were 34,034 new cases of pancreatic cancer and 33,021 deaths in the USA. From 2010 -2019, there was a 4% rise in the age-standardized rate (ASR) of new pancreatic cancer cases and mortality rate. In 2019, the highest incidence rates were in Louisiana (12.7/100 000), Mississippi (12.4/ 100 000), and the District of Columbia (12.1/100 000). The states with the highest increase in new cases over our study period were seen in North Dakota (13.7%), South Dakota (11.8%), and Vermont (11.5%). In terms of age-standardized mortality, the highest mortality rates in 2019 were seen in Louisiana (12.6/ 100 000), Mississippi (12.3/100 000), and the District of Columbia (11.9/ 100 000). Interestingly, the states with the highest increase in mortality over our study period were also North Dakota (13.8%), South Dakota (12.2%), and Vermont (11.5%). From 2010 – 2019, the incidence and mortality rates of pancreatic cancer increased in all states except Washington, the District of Columbia, Georgia, Connecticut, Nevada, and Hawaii. Louisiana had the highest age-standardized incidence of pancreatic cancer (12.7) and mortality rates (12.6) of pancreatic cancer.

Discussion: Overall, there is an increase in the incidence and mortality of pancreatic cancer across the United States. However, substantial differences exist across states, highlighting the need for localized strategies. Focused actions could be taken to address risk factors such as tobacco use, obesity, and alcohol consumption.


Disclosures:


Ooreoluwa Fasola, MD¹, Godfrey Tabowei, MD². P1747 - Age Standardized Incidence and Mortality Rates of Pancreatic Cancer in the United States From 2010-2019: Analysis From the Global Burden of Disease Database, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.