P2117 - Clinical Outcomes for Patients With Hyperlipidemia and Early Onset Colorectal Cancer: An Analysis of the National Inpatient Sample

Tony Elias, MS¹, Danielle C. Thor, DO, MA², Mujtaba Chohan, DO², Kyrillos Girgis, MD³, Rafail Beshai, DO^4
1Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ; ²Jefferson Health, Stratford, NJ; ³Newark Beth Israel Medical Center, Newark, NJ; ⁴Virtua Health System, Washington Township, NJ

Introduction: Despite recent global decreases in overall cancer incidence, early-onset colorectal cancer (EOCRC) is steadily increasing in incidence in western populations. Limited data is available on the comorbid correlations for this unfortunately expanding population. We sought to examine the national inpatient sample database to describe in-hospital outcomes among the patient population with hyperlipidemia (HLD) and EOCRC.

Methods: Data were extracted from the National Inpatient Sample (NIS) Database for 2019 and 2020. The NIS was searched for hospitalizations of adult patients with EOCRC, defined as colorectal cancer in patients 50 years old or younger. We then examined the outcomes of patients who were subsequently diagnosed with HLD. Multivariate logistic was used to adjust for confounders. The primary outcome was inpatient mortality. SPSS software was used for statistical analysis.

Results: This study included 11,820 patients with EOCRC, of which 1343 (11.4%) had been diagnosed with concurrent HLD. Patients with HLD had a higher prevalence of obesity (17.2% versus 9.4%, p< 0.001). Furthermore, patients with HLD had a higher prevalence of smoking (17.9% versus 16.3%, p< 0.001). Multivariate regression showed that patients with EOCRC and HLD had higher inpatient mortality (OR 1.102, CI 1.065-1.142, p< 0.001). On secondary analysis, it has shown that patients with EOCRC and HLD had higher odds of having non-alcoholic fatty liver disease (OR 1.243, CI 1.158-1.335, p< 0.001), inguinal hernia (OR 1.172, CI 1.020-1.348, p< 0.001), anemia (OR 1.130, CI 1.118-1.141, p< 0.001), thrombocytopenia (OR 1.134, CI 1.104 - 1.165, P< 0.001), peripheral artery disease (OR 1.167, CI 1.060-1.284, p< 0.001), hypertension (OR 1.505, CI 1.410-1.606, p< 0.001), acute kidney failure (OR 1.158, CI 1.134-1.183, p< 0.001), arrhythmias (OR 1.176, CI 1.120-1.235, p< 0.001), all-cause shock (OR 1.115, CI 1.078-1.236, p< 0.001), acute pancreatitis (OR 1.065, CI 1.103-1.119, p< 0.001), sepsis (OR 1.121, CI 1.104-1.138, p< 0.001), severe liver disease (OR 1.120, CI 1.108-1.132, p< 0.001), pulmonary embolism (OR 1.125, CI 1.097-1.154, p< 0.001), and deep vein thrombosis (OR 1.110, CI 1.072-1.149, p< 0.001).

Discussion: In this nationally representative, population‐based retrospective cohort study, patients with HLD and EOCRC were associated with higher mortality and worse outcomes.


Disclosures:


Tony Elias, MS¹, Danielle C. Thor, DO, MA², Mujtaba Chohan, DO², Kyrillos Girgis, MD³, Rafail Beshai, DO⁴. P2117 - Clinical Outcomes for Patients With Hyperlipidemia and Early Onset Colorectal Cancer: An Analysis of the National Inpatient Sample, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.