P2666 - Burden and Outcomes of Hypothyroidism Among Patients With Crohn's Disease

Ahmed Abomhya, MD¹, Ahmed Elmoursi, MD, MPH², Ahmed Elsayed, MD³, Karim Benrajab, MD¹, Ibrahim Metawea, MD⁴, Mustafa Alzubaidi, MD¹, Mohamed Ahmed, MBBCh^5
1University of Kentucky, Lexington, KY; ²Harvard Medical School, Lexington, KY; ³Baptist Memorial Hospital North Mississippi, Oxford, MS; ⁴University of Michigan, Ann Arbor, MI; ⁵Dar Alsalam Oncology Hospital, Cairo, Al Qahirah, Egypt

Introduction: Crohn’s disease (CD) is a chronic intestinal disorder that affects the digestive tract in a non-contiguous manner and carries a risk of multiple extraintestinal manifestations. Little is known about the burden of Hypothyroidism in patients with Crohn’s disease.

Methods: We conducted a nationwide retrospective cohort study to determine the prevalence and hospitalization outcomes associated with hypothyroidism in patients with CD. We collected data from the Healthcare Cost and Utilization Project (HCUP) Nationwide Readmission Databases (NRD) between 2016 and 2018. We extracted baseline demographic data, comorbidities, and admission outcomes including, length of hospital stays in days (LOS), total hospital charges, and mortality. Comparison between groups was performed by Chi-Square test for Categorical variables and Mann-Whitney test for continuous variables. Statistical analyses were performed using SPSS Version 25 (IBM Corporation, Armonk, NY, USA).

Results: We analyzed 214,622 index hospital discharges CD; 23,391(10.9%) patients had a comorbid diagnosis of hypothyroidism. CD patients were older (66; IQR: 54-76 vs 51; IQR: 35-66, P < 0.001) and more commonly to be female (76.9% vs 55.5%, P < 0.001) compared to CD patients without hypothyroidism respectively.

CD patients with hypothyroidism had increased LOS in days (4; IQR: 2-6 vs 3; IQR: 2-6, P < 0.001), higher median total charges ($33628; IQR: $18368-$64709 vs $30485; IQR: $16730-$58091, P < 0.001) and higher inpatient mortality rate (1.7% vs 1.1%, P < 0.001) compared to CD patients without hypothyroidism. There was no statistically significant difference in all-cause 30-day nonelective readmission rate (10.3% vs 10%, P= 0.166) between CD patients with and without hypothyroidism.

Discussion: Hypothyroidism is a common comorbidity among hospitalized CD patients and is associated with significantly higher morbidity and mortality. Clinicians must maintain a high index of suspicion for hypothyroidism so that it may be recognized and managed appropriately.


Disclosures:


Ahmed Abomhya, MD¹, Ahmed Elmoursi, MD, MPH², Ahmed Elsayed, MD³, Karim Benrajab, MD¹, Ibrahim Metawea, MD⁴, Mustafa Alzubaidi, MD¹, Mohamed Ahmed, MBBCh⁵. P2666 - Burden and Outcomes of Hypothyroidism Among Patients With Crohn's Disease, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.