P2667 - Adherence to Recommended Vaccines Among Individuals With Inflammatory Bowel Disease: Experiences From a Network of Resident Clinics

Thilini Delungahawatta, MD¹, Julie Suh, BS², Joseph Atarere, MD, MPH³, Jasmine Barrow, MD⁴, Christopher Haas, MD, PhD¹, Haider A. Naqvi, MD^5
1MedStar Health, Baltimore, MD; ²Georgetown University, Washington, DC; ³MedStar Union Memorial Hospital, Baltimore, MD; ⁴MedStar Franklin Square Medical Center, Baltimore, MD; ⁵MedStar Franklin Square Medical Center, Rossville, MD

Introduction: Inflammatory bowel disease (IBD) is an immune-mediated inflammatory condition affecting 1.3% of the U.S. population. Due to dysregulated immune responses and frequent use of immunosuppressive therapies, IBD patients are susceptible to opportunistic infections. Despite established vaccination guidelines for infection prevention in this population, vaccination rates among IBD patients remain suboptimal.

Methods: We conducted a mixed-methods cross-sectional study on adults with an ICD-10 diagnosis of IBD at six internal and family medicine residency clinics in Baltimore, from June 2020 to December 2022. Data collection occurred in two stages between June 2023 to January 2024. In the first stage, demographic and relevant data were abstracted from electronic medical records, and in the second stage, participants not up to date with recommended vaccines were contacted to collect information on reasons for non-adherence.

Results: Among the 110 IBD patients studied, 75 had Crohn’s disease (CD) and 35 had Ulcerative Colitis (UC), with majority being female and average age of 48 years; 34.9% were Black. Over two-fifths were currently using at least one immunosuppressive medication. About 73.3% had received at least one influenza vaccination, with UC patients being more likely than CD patients to be up to date with influenza vaccination (60.0% vs 32.9%). For DTaP vaccination, 74.3% of patients were up to date and only 11.9% had not received the vaccine. Hepatitis B vaccination rates were low, with 74.6% not having received the vaccine and only 13.6% completing the three-dose series. COVID-19 vaccination adherence showed that 12.1% of patients did not receive any doses, while 55.0% had received two doses and a booster. Missingness in data was >20% for other recommended vaccinations. After adjusting for age, patients on immunosuppressive medications were more likely to be up to date with influenza [OR 3.25, 95% CI (1.27, 8.30)] and COVID-19 vaccinations [OR 2.64, 95% CI (1.09, 6.37)]. Of the 36 respondents included in the second stage, 25% were unaware of the need for vaccination, 22.2% did not share their reasons for non-adherence, 17% planned to get vaccinated and 8% cited safety concerns.

Discussion: Although influenza and DTaP vaccination rates were comparatively elevated, significant gaps persist in adherence to vaccination guidelines among individuals with IBD. The findings demonstrate a need to prioritize educational interventions targeting both patients and providers.



Disclosures:


Thilini Delungahawatta, MD¹, Julie Suh, BS², Joseph Atarere, MD, MPH³, Jasmine Barrow, MD⁴, Christopher Haas, MD, PhD¹, Haider A. Naqvi, MD⁵. P2667 - Adherence to Recommended Vaccines Among Individuals With Inflammatory Bowel Disease: Experiences From a Network of Resident Clinics, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.