P4618 - Sex Disparities in Characteristics and Outcomes of Patients With Alcoholic Hepatitis: A Retrospective Analysis via the National Inpatient Sample

Kyaw Min Tun, DO¹, Renuka Verma, MD², Hemamalini Sakthivel, MD³, Kamleshun Ramphul, MD⁴, Banreet Dhindsa, MD⁵, Douglas Adler, MD^6
1Creighton University School of Medicine, Las Vegas, NV; ²University of Nevada, Las Vegas, NV; ³One Brooklyn Health-Interfaith Medical Center, New York, NY; ⁴Independent Researcher, Triolet, Pamplemousses, Mauritius; ⁵NYU Grossman School of Medicine, New York, NY; ⁶Center for Advanced Therapeutic (CATE), Centura Health, Porter Adventist Hospital, Peak Gastroenterology, Denver, CO

Introduction: Recent studies have highlighted concerning reports of rising alcohol use trends in the United States, especially among women, with a rising number of deaths linked to excessive alcohol use. As women could be more susceptible to liver damage despite consuming less alcohol due to varying metabolic and hormonal factors, we aim to understand the sex-based disparities in characteristics and outcomes following admission for alcoholic hepatitis.

Methods: Hospitalization records of cases with a primary diagnosis of alcohol hepatitis were evaluated from the 2016-2021 National Inpatient Sample. We excluded cases ages < 18 years, with a diagnosis of COVID-19, and missing data for sex. Chi-Square and Mann-Whitney U tests helped evaluate patient characteristics. Multivariable regression analyses were used to understand the differences in outcomes and expressed as adjusted odds ratio(aOR), 95% confidence interval(95% CI), and p-values.

Results: An estimated 114525 patients met our selection criteria, involving 67220(58.7%) males and 47305(41.3%) females. Males were older (median age 46.00(IQR 37.00-55.00) vs. 45.00(IQR 36.00-53.00), p< 0.01)(mean age 46.26 vs. 45.05). Various differences in baseline demographics and comorbidities were noted between males and females as described in Table 1a. In addition, Females expressed lower odds of multiple complications including hyponatremia, ascites, hepatopulmonary syndrome, hepatorenal syndrome, variceal GI bleed, cardiogenic shock, acute kidney injury, cardiac arrest, and use of mechanical ventilation than males, while having higher odds of severe sepsis. Overall, Females also expressed lower odds of all-cause mortality during their hospitalization(Table 1b).

Discussion: Our study confirmed that women admitted for alcohol hepatitis were less prone to multiple short-term complications and mortality while having higher odds of severe sepsis. More studies should be encouraged and advocated to understand the short- and additional long-term complications and bring about changes to bridge the observed sex-based differences.


Disclosures:


Kyaw Min Tun, DO¹, Renuka Verma, MD², Hemamalini Sakthivel, MD³, Kamleshun Ramphul, MD⁴, Banreet Dhindsa, MD⁵, Douglas Adler, MD⁶. P4618 - Sex Disparities in Characteristics and Outcomes of Patients With Alcoholic Hepatitis: A Retrospective Analysis via the National Inpatient Sample, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.