P4663 - Trends in Mortality Due to Non-Alcoholic Fatty Liver Disease Among Patients Aged 25 and Older in the United States: Insights from the CDC WONDER Database

Ammad Javaid. Chaudhary, MD¹, Muhammad Zarrar Khan, MD², Muhammad Naveed, MBBS³, Ali Jaan, MD⁴, Rabia Iqbal, MBBS³, Muhammad Omer Rehan, MBBS³, Bazil Azeem, MBBS⁵, Ahila Ali, MBBS³, Huzaifa Ansari, MBBS⁶, Faizan Ahmed, MBBS⁷, Hameed Ullah, MD⁸, Syed-Mohammed Jafri, MD^1
1Henry Ford Health, Detroit, MI; ²Henry Ford Hospital, Royal Oak, MI; ³Dow Medical College, Karachi, Sindh, Pakistan; ⁴Rochester General Hospital, Rochester, NY; ⁵Shaheed Mohtarma Benazir Bhutto Medical College, Karachi, Sindh, Pakistan; ⁶Dow University of Health Sciences, Karachi, Sindh, Pakistan; ⁷Ameer Ud Din Medical College/ Lahore General Hospital, Lahore, Punjab, Pakistan; ⁸Saint Luke's Hospital, St. Louis, MO

Introduction: Non-Alcoholic Fatty Liver Disease (NAFLD) is an emerging health concern with increasing mortality rates. This study examines trends and demographic disparities in mortality due to NAFLD among adults aged 25 and older in the United States from 1999 to 2020.

Methods: A retrospective analysis was conducted using death data from the CDC WONDER database spanning 1999-2020. Age-adjusted mortality rates (AAMRs) per 100,000 persons were calculated, and trends assessed using Average Annual Percentage Change (AAPC) and Annual Percent Change (APC). Data were stratified by year, sex, race/ethnicity, and geographical regions.

Results: Between 1999 and 2020, NAFLD accounted for 71,623 deaths among adults aged 25+ in the U.S. Deaths primarily occurred in medical facilities (37.8%) and at decedents’ homes (40.9%). The overall AAMR for NAFLD-related deaths increased from 1.1 in 1999 to 3.1 in 2020, with an AAPC of 5.29 (95% CI: 4.80 to 6.04, p < 0.000001). AAMR showed a minor increase from 1999 to 2012 (APC: 1.32, p = 0.150), followed by a striking rise from 2012 to 2020 (APC: 12.07, p < 0.000001). Men exhibited slightly higher AAMRs compared to women (men: 1.6; women: 1.4). The AAMR of women showed a significant increase than men. Racial disparities were evident, with Americans having the highest AAMR (3.7), followed by Hispanics (1.7), Whites (1.6), Blacks (0.9), and Asians (0.6). All racial groups experienced increased AAMRs except Black individuals, who saw a decrease. The increase was most pronounced in Americans (AAPC: 6.08, p < 0.000001).Geographically, AAMRs ranged from 0.8 in Alabama to 2.5 in Oklahoma. The Western region had the highest average AAMR (2.1). Nonmetropolitan areas exhibited higher AAMRs than metropolitan areas (nonmetropolitan: 1.6; metropolitan: 1.5).

Discussion: This study reveals the notable increase in mortality rates due to NAFLD in past two decades. Our target population was adult liver disease patients aged 25 and above in the United States. Interestingly, the AAMR has nearly tripled from 1999 to 2020. The results highlights the disparities in race trends and geographic regions. Thus, there is an urgent need for focused interventions which would improve overall health outcomes.



Disclosures:


Ammad Javaid. Chaudhary, MD¹, Muhammad Zarrar Khan, MD², Muhammad Naveed, MBBS³, Ali Jaan, MD⁴, Rabia Iqbal, MBBS³, Muhammad Omer Rehan, MBBS³, Bazil Azeem, MBBS⁵, Ahila Ali, MBBS³, Huzaifa Ansari, MBBS⁶, Faizan Ahmed, MBBS⁷, Hameed Ullah, MD⁸, Syed-Mohammed Jafri, MD¹. P4663 - Trends in Mortality Due to Non-Alcoholic Fatty Liver Disease Among Patients Aged 25 and Older in the United States: Insights from the CDC WONDER Database, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.