P1918 - The Association Between Pyogenic Liver Abscess and Increased Incidence of Colorectal Cancer Across Age Groups and in Patients With Diabetes Mellitus: A Meta-Analysis and Systematic Review
AdventHealth Medical Group, AdventHealth Orlando, FL
Nouman Shafique, MD1, Fnu Muhibullah, MD, MBBS2, Abdul Qadeer, 3, Ali Raza Khan, MBBS3, Abdul Wasay, MD4, Adeena Shafique, 5, Shahzad Zafar, MBBS3, Iqra Shafiq, MBBS6, Sana Asif, MBBS3, Salman Khan, MD3, Amna Ehsan, MBBS7, Gul Nawaz, MD8, Ahmad Khan, MD9, Abu Hurairah, MD1 1AdventHealth Medical Group, AdventHealth, Orlando, FL; 2West Virginia University Camden Clark Medical Center, Parkersburg, WV; 3Nishtar Medical University, Multan, Punjab, Pakistan; 4University of Tennessee Medical Center, Knoxville, TN; 5Aga Khan University, Karachi, Sindh, Pakistan; 6Combined Military Hospital, Bahawalpur, Punjab, Pakistan; 7Nishtar Medical University, Parkersburg, WV; 8Marshfield Medical Center, Marshfield, WI; 9University Hospitals Cleveland Medical Center, Cleveland, OH
Introduction: Pyogenic liver abscess (PLA) is a significant clinical condition with potential implications for colorectal cancer (CRC) incidence. Previous studies suggest a possible link between PLA and an increased risk of CRC, yet the relationship remains unclear. Our study aims to evaluate the incidence of CRC in patients with PLA, focusing on age-specific variations and the presence of DM.
Methods: We did a comprehensive literature search using PubMed, EMBASE, and Cochrane Library, to identify studies reporting the incidence of CRC in patients with PLA. We included studies that compared the incidence of CRC in patients with and without PLA across different age groups and DM status. A random-effects model was used to pool effect sizes from the extracted data. The primary endpoint was the incidence of CRC.
Results: We included 5 studies in our analysis including 39,631 patients. Our results exhibited a statistically significant higher incidence of CRC in patients with PLA across different age groups. Specifically, for patients under 60 years old, the pooled odds ratio (OR) was 3.83 (95% CI: 1.31 to 11.16) in patients with PLA compared to those without PLA (I²=0%; p=0.01). For patients over 60 years old, the pooled OR was 2.86 (95% CI: 1.23 to 6.65) in patients with PLA (I²=0%; p=0.01). The overall analysis for all age groups combined showed a pooled OR of 3.20 (95% CI: 1.65 to 6.20), with no significant heterogeneity (I²=0%; p=0.0006). For the incidence of CRC in patients with DM, the pooled OR was 1.48 (95% CI: 0.99 to 2.19), suggesting a non-significant trend toward a higher incidence of CRC in patients with DM (I²=4%; p=0.05). The overall incidence of CRC in patients with PLA showed a pooled OR of 3.16 (95% CI: 1.83 to 5.45), indicating a significantly higher incidence of CRC in these patients (I²=64%; p< 0.0001).
Discussion: This meta-analysis demonstrates a significant association between the presence of pyogenic liver abscess and the incidence of colorectal cancer across different age groups. The incidence is higher in both younger (< 60 years) and older ( >60 years) patients with PLA. Although there is a trend towards increased CRC incidence in patients with DM, the association is not statistically significant. The overall analysis confirms a strong association between the presence of PLA and increased CRC incidence. However, further research is needed to explore the relationship between DM and CRC incidence more comprehensively.
Figure: Forest plot for A) Incidence of CRC with Age B) Incidence of CRC with DM C) Overall incidence of CRC
Disclosures:
Nouman Shafique indicated no relevant financial relationships.
Fnu Muhibullah indicated no relevant financial relationships.
Abdul Qadeer indicated no relevant financial relationships.
Ali Raza Khan indicated no relevant financial relationships.
Abdul Wasay indicated no relevant financial relationships.
Adeena Shafique indicated no relevant financial relationships.
Shahzad Zafar indicated no relevant financial relationships.
Iqra Shafiq indicated no relevant financial relationships.
Sana Asif indicated no relevant financial relationships.
Salman Khan indicated no relevant financial relationships.
Amna Ehsan indicated no relevant financial relationships.
Gul Nawaz indicated no relevant financial relationships.
Ahmad Khan indicated no relevant financial relationships.
Abu Hurairah indicated no relevant financial relationships.
Nouman Shafique, MD1, Fnu Muhibullah, MD, MBBS2, Abdul Qadeer, 3, Ali Raza Khan, MBBS3, Abdul Wasay, MD4, Adeena Shafique, 5, Shahzad Zafar, MBBS3, Iqra Shafiq, MBBS6, Sana Asif, MBBS3, Salman Khan, MD3, Amna Ehsan, MBBS7, Gul Nawaz, MD8, Ahmad Khan, MD9, Abu Hurairah, MD1. P1918 - The Association Between Pyogenic Liver Abscess and Increased Incidence of Colorectal Cancer Across Age Groups and in Patients With Diabetes Mellitus: A Meta-Analysis and Systematic Review, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.