P1922 - Temporal Trends in the Incidence of Colorectal Cancer in Canada for the Past 3 Decades

Ahmed A. Abdulelah, MD¹, Yazan Gharaibeh, MD², Zaid A. Abdulelah, MD³, Mohammad Alqaisieh, MD⁴, Lina AlQirem, MD⁵, Dua' Al-Husni, MD⁶, Hussein Abdulelah, MD⁷, Amer Khatib, MD^7
1University of Edinburgh, Edinburgh, Scotland, United Kingdom; ²Royal Free London NHS Trust, London, England, United Kingdom; ³Royal Papworth Hospital, Cambridge, England, United Kingdom; ⁴Hamilton Medical Center, Dalton, GA; ⁵University of Arkansas for Medical Sciences, Little Rock, AR; ⁶Cleveland Clinic Foundation, Cleveland, OH; ⁷University of Jordan, Amman, 'Amman, Jordan

Introduction: Colorectal cancer (CRC) is among the most prevalent malignancies worldwide and is regarded to be the most prevalent among males in certain regions and countries. Thus, the identification of temporal trends in the incidence of CRC is of particular significance in the introduction of effective preventative measures and health policies.

Methods: The incidence of CRC in Canada over the past 30 years was initially evaluated by utilizing the Global Burden of Diseases 2019 database. The temporal trends were assessed through the Joinpoint Analysis software that was used to calculate the Annual Percentage Change (APC) and the Average Annual Percentage Change (AAPC), stratified by age and gender.

Results: Over the time period of 1990-2019, a total of 713,270 CRC cases have been reported in Canada with a male predominance of 54.1%. Stratification by age revealed 2 Joinpoints among the 15-49 years old age group with a statistically significant incline in the incidence of CRC (AAPC 1.70; 95%CI 1.582 to 1.82; p< 0.001). Interestingly, the 50-74 years old age group had a statistically significant decline in the incidence of CRC with an AAPC of -0.37 (95%CI -0.45 to -0.30; p< 0.001). Whereas in the 75+ years old age group, a statistically significant increase in incidence was observed with an AAPC of 0.28 (95%CI 0.21 to 0.34; p< 0.001). In terms of stratification by gender, both males and females demonstrated a statistically significant increase in CRC incidence that was more notable in males, who had 2 identified Joinpoints, with an AAPC of 1.99 (95%CI 1.91 to 2.05; p< 0.001), while females had 3 identified Joinpoints and an AAPC of 1.38 (95%CI 1.31 to 1.47; p< 0.001).

Discussion: Over the past 30 years, CRC incidence in Canada observed a significant incline in the 15-49 years old and 75+ years old age groups coupled with a decline in the incidence among individuals aged 50-74 years old. Such findings can be explained by increased uptake of screening modalities. Nonetheless, an increment in CRC incidence was noted in both males and females, thus mandating prompt measures and interventions.


Disclosures:


Ahmed A. Abdulelah, MD¹, Yazan Gharaibeh, MD², Zaid A. Abdulelah, MD³, Mohammad Alqaisieh, MD⁴, Lina AlQirem, MD⁵, Dua' Al-Husni, MD⁶, Hussein Abdulelah, MD⁷, Amer Khatib, MD⁷. P1922 - Temporal Trends in the Incidence of Colorectal Cancer in Canada for the Past 3 Decades, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.