University Clinical center of Serbia Belgrade, Vojvodina, Serbia
Milica Stojkovic Lalosevic, MD, PhD, Aleksandra Pavlovic Markovic, MD, PhD, Zlatibor Loncar, MD, PhD University Clinical center of Serbia, Belgrade, Vojvodina, Serbia
Introduction: Background: IgG4-related sclerosing cholangitis is rare disease, presented as a biliary manifestation of IgG4-related disease. Although serum levels of IgG4 are important in diagnosis establishment, it is still unclear whether they correlate with the disease activity.
Aim: To investigate the correlation of serum IgG4 with laboratory parameters of cholangitis.
Methods: Levels of IgG4 from serum of 22 patients with established diagnosis of IgG4-related sclerosing cholangitis were analyzed by nephelometry. Patients were divided in two groups based on the levels of serum IgG4, bearing in mind referent values of 1.35g/L. Statistical analyses included descriptive statistics, Student’s t test, Spearman’s correlation.
Results: In patients with IgG4-related sclerosing cholangitis, 11 (50%) were female, with mean age of 40 years (ranging from 18 to 61). Mean concentration of serum IgG4 was 2.84 g/L. Levels in female patients were statistically significantly higher compared to male (F=5.041, P=0.049). Furthermore levels of alkaline phosphatase, as well as serum amylase and lipase were significantly higher in the group of patients with elevated IgG4 (P=0.04, P=0.05 and P=0.05) respectively. Moreover, elevated parameters of systemic inflammation were seen in the group of patients with elevated IgG4, ESR, CRP, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio (P=0.03, P=0.05, P=0.04, and P=0.05).
Discussion: Conclusion: Our results show that IgG4 levels significantly correlate with activity markers of IgG4-related sclerosing cholangitis.
Disclosures:
Milica Stojkovic Lalosevic indicated no relevant financial relationships.
Aleksandra Pavlovic Markovic indicated no relevant financial relationships.
Zlatibor Loncar indicated no relevant financial relationships.
Milica Stojkovic Lalosevic, MD, PhD, Aleksandra Pavlovic Markovic, MD, PhD, Zlatibor Loncar, MD, PhD. P0042 - IgG4 Levels Correlate With Disease Activity in Patients With IgG4-Related Sclerosing Cholangitis, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.
