Raj Mohan Ram Mohan, MD, Sai Reshma Magam, MD, Sai Greeshma Magam, MD, Melvin Joy, MD, Dilman Natt, MD, Winghang Lau, MD, Abhishek Tadikonda, MD, Leeza Pannikodu, MD, Jiten Desai, MD, Krishnaiyer Subramani, MD, Paul Mustacchia, MD, MBA Nassau University Medical Center, East Meadow, NY
Introduction: Ischemic colitis, marked by reduced colon blood flow, varies in incidence among races, especially in IBS patients. This variation stems from a complex mix of genetic, environmental, and healthcare factors. Research highlights how genetic susceptibility, comorbidities, healthcare access, and socioeconomic status influence these racial disparities. Recognizing the role of race is crucial in managing IBS and ischemic colitis, ensuring equitable and effective treatment for all.
Methods: From 2009 to 2023, our study retrospectively analyzed IBS patients who developed ischemic colitis, gathering data on comorbidities, insurance, and socioeconomic factors using CPT and ICD codes. We used a chi-square test to explore the relationship between race and the incidence of ischemic colitis. Additionally, we applied a survival analysis using the Kaplan-Meier method to estimate the probability that individuals of different racial groups would remain free from ischemic colitis over time. This comprehensive methodological approach allowed for a detailed examination of the data.
Results: In this study, 174 patients participated, with 94 (54%) being female. Of these patients, 35 (19%) developed Ischemic colitis. Notably, the distribution of Ischemic Colitis cases by race varied significantly. Hispanics had the highest percentage at around 6.4% (Chi-square stat: 3.59, P< 0.01), compared to African Americans 2.7%, Asians 2.1%, and Whites 2.1%. The data also revealed differences regarding the average time to develop IBS, with Hispanics averaging 107 months, Asians 113.4 months, African Americans 121.2 months, and Whites 121 months (Breslow: 2.45, p< 0.01). Hispanic patients with low socioeconomic status showed an increased incidence of ischemic colitis(Chi sq: 4.59, P< 0.01).
Discussion: The study explored the relationship between race and the incidence of ischemic colitis in patients with Irritable Bowel Syndrome (IBS). It found significant disparities in both the prevalence and time to develop IBS-related ischemic colitis among racial groups. Hispanics had the highest incidence and developed IBS more quickly, while African Americans and Whites had lower rates and longer average development times. These findings highlight the complexity of genetic, environmental, and healthcare-related factors contributing to these disparities, emphasizing the need for equitable healthcare considerations in managing IBS and ischemic colitis across diverse patient populations.
Figure: Ischemic Colitis in IBS patients
Note: The table for this abstract can be viewed in the ePoster Gallery section of the ACG 2024 ePoster Site or in The American Journal of Gastroenterology's abstract supplement issue, both of which will be available starting October 27, 2024.
Disclosures:
Raj Mohan Ram Mohan indicated no relevant financial relationships.
Sai Reshma Magam indicated no relevant financial relationships.
Sai Greeshma Magam indicated no relevant financial relationships.
Melvin Joy indicated no relevant financial relationships.
Dilman Natt indicated no relevant financial relationships.
Winghang Lau indicated no relevant financial relationships.
Abhishek Tadikonda indicated no relevant financial relationships.
Leeza Pannikodu indicated no relevant financial relationships.
Jiten Desai indicated no relevant financial relationships.
Krishnaiyer Subramani indicated no relevant financial relationships.
Paul Mustacchia indicated no relevant financial relationships.
Raj Mohan Ram Mohan, MD, Sai Reshma Magam, MD, Sai Greeshma Magam, MD, Melvin Joy, MD, Dilman Natt, MD, Winghang Lau, MD, Abhishek Tadikonda, MD, Leeza Pannikodu, MD, Jiten Desai, MD, Krishnaiyer Subramani, MD, Paul Mustacchia, MD, MBA. P0630 - Intersectionality of Race and Socioeconomics in Ischemic Colitis Incidence Within IBS Populations, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.
