P1530 - Statewide Burden of Peptic Ulcer Disease in the United States and its Trend From 1990-2021: A Benchmarking Systematic Analysis for the Global Burden of Disease Study 2021

Janmay Vala, MBBS¹, Sravani Bhavanam, MBBS, MD², Nanki Singh, MBBS³, Mandeepsinh Vashi, MBBS⁴, Aishwar Dixit, MBBS⁵, George Mathew Mukalil, MD⁶, Muhammad Waqas, MBBS⁷, Ashwinikumar Shandilya, MBBS⁸, Bhargav Koyani, MD⁹, Awan Muhammad Raheel, MBBS, MD¹⁰, Mohit Lakkimsetti, MBBS¹¹, Vishrant P. Amin, MBBS¹², Juhi R. Patel, MBBS¹³, Hardik Dineshbhai. Desai, MBBS^14
1Terna Medical College, Boisar, Maharashtra, India; ²One Brooklyn Health-Brookdale University Hospital Medical Center, Brooklyn, NY; ³School of Medical Sciences and Research, Noida, Uttar Pradesh, India; ⁴Surat Municipal Institute of Medical Education and Research (SMIMER), Surat, Gujarat, India; ⁵Baba Raghav Das Medical College, Lucknow, Uttar Pradesh, India; ⁶Central Michigan University, Saginaw, MI; ⁷Jinnah Sindh Medical University, Karachi, Sindh, Pakistan; ⁸Rural Medical College, Pravara Institute of Medical Sciences, Ahmednagar, Maharashtra, India; ⁹Saint Francis Hospital, Evanston, Evanston, IL; ¹⁰Carle Health, Urbana, IL; ¹¹Mamata Medical College, Khammam, Telangana, India; ¹²GMERS Medical College Valsad, Ahmedabad, Gujarat, India; ¹³GMERS Medical College and Hospital Valsad, Ahmedabad, Gujarat, India; ¹⁴Gujarat Adani Institute of Medical Sciences, Ahmedabad, Gujarat, India

Introduction: Peptic Ulcer Disease (PUD) is increasingly becoming a public health concern in the United States. There remains a lack of consistent and comparative data on PUD in the USA. This study represents the first comprehensive estimation of the PUD burden across the last three decades in the USA, including the initial two years of the COVID-19 pandemic, which posed significant challenges in managing non-COVID-19 cases.



Methods: Utilizing the Global Burden of Disease tool, we estimated the incidence, prevalence, deaths, and disability-adjusted life years (DALYs) associated with PUD, stratified by age, sex, year, and location across the USA from 1990 to 2021. Non-fatal health outcomes were estimated using the DISMOD MR-2.1 meta-regression tool, while fatal health outcomes were derived from the Cause of Death Ensemble Model (CODEm).

Results: The total prevalence count of Peptic Ulcer Disease (PUD) in the U.S. rose from 375,151 (95% uncertainty interval: 314,701-451,354) in 1990 to 485,057 (419,149-560,778) in 2021. The total percentage change (TPC) in the age-standardized incidence rate (ASIR) decreased by 21%, while the age-standardized mortality rate (ASMR) and the age-standardized disability-adjusted life years rate (ASDALR) decreased by 66% and 58% respectively from 1990 to 2021. The highest TPC in ASIR was observed in Massachusetts with a 26% decrease, and the smallest was in Alabama at 15%. In terms of ASMR, the greatest reduction was seen in South Dakota at 61%. Age-wise, the highest incidence count in 2021 was in individuals aged 70-74 years, with 29,610 cases (95% UI: 19,345-40,820), while the highest number of deaths occurred in the 85-89 age group with 556 (439-621), and the highest DALYs were in the 70-74 age group with 12,447 (11,237-13,960). Over the past three decades, males consistently exhibited a higher burden of disease compared to females.

Discussion: Despite a decreasing trend, the overall burden of Peptic Ulcer Disease (PUD) remains high, emphasizing the need for ongoing public health initiatives, effective policy-making, and updated clinical practices. Public health officials must continue prioritizing PUD by focusing on prevention and management strategies, while policymakers need to ensure adequate resource allocation for improved care. Clinicians should keep current with treatment advancements and prevention techniques to effectively manage and educate patients, helping to further alleviate the disease's impact.





Disclosures:


Janmay Vala, MBBS¹, Sravani Bhavanam, MBBS, MD², Nanki Singh, MBBS³, Mandeepsinh Vashi, MBBS⁴, Aishwar Dixit, MBBS⁵, George Mathew Mukalil, MD⁶, Muhammad Waqas, MBBS⁷, Ashwinikumar Shandilya, MBBS⁸, Bhargav Koyani, MD⁹, Awan Muhammad Raheel, MBBS, MD¹⁰, Mohit Lakkimsetti, MBBS¹¹, Vishrant P. Amin, MBBS¹², Juhi R. Patel, MBBS¹³, Hardik Dineshbhai. Desai, MBBS¹⁴. P1530 - Statewide Burden of Peptic Ulcer Disease in the United States and its Trend From 1990-2021: A Benchmarking Systematic Analysis for the Global Burden of Disease Study 2021, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.