University of Missouri - Kansas City School of Medicine KANSAS CITY, MO
Obieda Altobaishat, MD1, Mohammad Adam, MD, MSc2, Islam Mohamed, MD2, Omar Abdullah Bataineh, MD1, Osama Alzoubi, MD1, Mohamed Abouzid, PharmD, PhD3 1Jordan University of Science and Technology, Irbid, Irbid, Jordan; 2University of Missouri - Kansas City School of Medicine, Kansas City, MO; 3Poznan University of Medical Sciences, Poznan, Wielkopolskie, Poland
Introduction: Digestive diseases are prevalent all over the world, accounting for a significant portion of health-care use and costs. Jordan, a middle-income Arab country, is distinguished by its dual-sector healthcare system, political stability, and significance as a refugee and migrant destination. These distinguishing characteristics highlight Jordan's attractiveness as a case study. However, Arab countries continue to lack public health data and are severely understudied in health research, so the goal of this study is to quantify the burden of digestive diseases in Jordan and identify risk factors, contributing to a greater awareness of healthcare challenges in the Arab region and beyond.
Methods: From 1990 to 2021, age-standardized rates of prevalence, death, and disability-adjusted life years (DALYs) were estimated using the Global Burden of Disease (GBD) dataset. We measured the percentage change for eighteen major digestive diseases and presented the results by age and gender. Additionally, data on alcohol and tobacco use as a risk factor attributing to overall age-standardized digestive diseases DALY were reported per 100,00 population.
Results: The data reveal a concerning rise in the all-age prevalence of various digestive diseases between 1990 and 2021. Notably, nonalcoholic fatty liver disease including cirrhosis, demonstrates the most dramatic increase, with a staggering 500% growth (from 545,733 to 3,272,802). In 2021, the age-standardized digestive diseases prevalence, death, and DALYs rates in Jordan were 543 (95% uncertainty interval [UI] 446, 660), 15 (95% UI 12, 18), and 543 (95% UI 446, 660), respectively. Also, the data reveal a concerning association between alcohol and tobacco use and various digestive conditions.
Discussion: Digestive disease represents a huge burden in Jordan with a significant rise in prevalence, DALY & mortality over the last 2 decades (356%, 118% & 161% respectively). It jumped from the 15th to 13th leading cause of DALY Worldwide; cirrhosis and other chronic liver diseases represent the leading cause of morbidity & mortality in Jordan. There is a significant decrease in the age-adjusted Prevalence of DALY & mortality of Chronic Hep. B and C & Alcohol; but Nonalcoholic fatty liver disease including cirrhosis shows a modest decrease between 1990 and 2019. Digestive disease burden in Jordan is a complex issue with contributing factors which require further studies and exploring the literature that improve public health policy plans.
Figure: Disease Mortality & Morbidity Trend
Note: The table for this abstract can be viewed in the ePoster Gallery section of the ACG 2024 ePoster Site or in The American Journal of Gastroenterology's abstract supplement issue, both of which will be available starting October 27, 2024.
Disclosures:
Obieda Altobaishat indicated no relevant financial relationships.
Mohammad Adam indicated no relevant financial relationships.
Islam Mohamed indicated no relevant financial relationships.
Omar Abdullah Bataineh indicated no relevant financial relationships.
Osama Alzoubi indicated no relevant financial relationships.
Mohamed Abouzid indicated no relevant financial relationships.
Obieda Altobaishat, MD1, Mohammad Adam, MD, MSc2, Islam Mohamed, MD2, Omar Abdullah Bataineh, MD1, Osama Alzoubi, MD1, Mohamed Abouzid, PharmD, PhD3. P1512 - The Burden of Digestive Diseases in Jordan: A Longitudinal Analysis of Global Burden of Disease Study, 1990-2021, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.
