P0881 - Trends in the Prevalence of Diagnosed Inflammatory Bowel Disease among Asian Subgroups in a Large Northern California Population

Award: Presidential Poster Award

Chandni Kapoor, MD¹, Julia Wei, MPH², Nirmala Ramalingam, MPP³, Benjamin Hassid, MD^1
1Kaiser Permanente, Oakland, CA; ²Kaiser Permanente Northern California, Pleasanton, CA; ³Kaiser Permanente Oakland Medical Center, Oakland, CA

Introduction: The prevalence of inflammatory bowel disease (IBD) continues to increase but the burden varies by ethnicity. Previous studies demonstrate that the burden of IBD among adults is higher in White adults compared to Asian adults. However, when Asians are sub-classified, a higher prevalence of IBD among South Asian (SA) compared to other major Asian sub-groups has been observed. Our study examines the variation in IBD prevalence in a large and contemporary US Asian population.

Methods: Using data from Kaiser Permanente Northern California, adults age ≥18 years were examined for IBD diagnosis during 1/1/2018-12/31/2018, based on ICD-10 diagnosis codes for Ulcerative Colitis (UC, K51.x) and Crohn’s disease (CD, K50.x). Prevalence of IBD, UC and CD was calculated by race and ethnicity, including Asian subtypes.

Results: Among 3,675,554 adults (19% Asian, 7% Black, 19% Hispanic, 43% non-Hispanic White (NHW), and 12% mixed/other/unknown), 10,196 had a diagnosis of IBD (59% UC, 41% CD). The prevalence of IBD was higher among NHW (415 per 100,000) compared to Asian adults (119 per 100,000, Table). Among Asian subgroups, those of SA ethnicity had much higher IBD prevalence (488 per 100,000) compared to other Asian subgroups, in the range of and exceeding that of NHW adults. Next highest was Japanese ethnicity (127 per 100,000).

When the IBD subtypes CD and UC were specifically examined, prevalence among Asian adults in aggregate was lower compared to NHW adults. However, amongst SA adults, the prevalence of UC was much higher than NHW adults (418 vs 234 per 100,000), whereas prevalence of CD was substantively lower (70 vs 181 per 100,000, Table).

Discussion: In a large and ethnically diverse US population, the prevalence of IBD was highest for NHW, intermediate for Black and Hispanic adults, and lower for Asian adults. However, there was large variation among major Asian subgroups, with IBD prevalence highest among SA adults, that was largely driven by the much higher UC prevalence among SA adults (that also exceeded NHW adults). This contemporary study points to key differences in the prevalence of IBD and especially UC among Asian ethnic subgroups that should be further studied. Future studies should also examine trends in the incidence of IBD and UC among US Asian ethnic populations.


Disclosures:


Chandni Kapoor, MD¹, Julia Wei, MPH², Nirmala Ramalingam, MPP³, Benjamin Hassid, MD¹. P0881 - Trends in the Prevalence of Diagnosed Inflammatory Bowel Disease among Asian Subgroups in a Large Northern California Population, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.