P0052 - Sarcopenia is Associated With Increased Mortality And Resource Utilization in Patients With Chronic Pancreatitis: Analysis of National Inpatient Sample 2016-2020

Anmol Singh, MBBS¹, Sahiljot Bhupal, MBBS², Carol Singh, MBBS³, Vikash Kumar, MD⁴, Ritika Dhruve, MBBS⁵, Aalam Sohal, MD⁶, Juliana Yang, MD^7
1Tristar Centennial Medical Center, Nashville, TN; ²Dayanand Medical College and Hospital, Chicago, IL; ³Dayanand Medical College and Hospital, Jalandhar, Punjab, India; ⁴Creighton University School of Medicine, Brooklyn, NY; ⁵University of Texas Southwestern Medical Center, Dallas, TX; ⁶Creighton University School of Medicine, Seattle, WA; ⁷University of Texas Medical Branch, Galveston, TX

Introduction: Malnutrition is a common sequela of chronic pancreatitis (CP), which can lead to the development of secondary sarcopenia. Recent studies have suggested that sarcopenia may be associated with adverse outcomes in CP patients. The current study examines the impact of sarcopenia on outcomes in patients with CP.

Methods: We used the National Inpatient Sample 2016-2020 to identify adult patients ( >18 yrs) with CP. Patients were stratified into two groups based on the presence of sarcopenia. Patients with missing demographics or mortality were excluded. Data was collected on patient demographics, hospital characteristics, and comorbidities. The outcomes assessed were in-hospital mortality, sepsis, shock, acute kidney injury and resource utilization. Multivariate regression analysis was used to assess the relationship between sarcopenia and clinical outcomes in patients with chronic pancreatitis.

Results: Of 907,790 patients with CP, 165,900 (18.3%) had sarcopenia. The majority of patients with sarcopenia were Male (55.9%), White (65.8%), and had Medicare insurance (44.5%). Patients with sarcopenia had higher in-hospital mortality (4.7% vs. 1.2%,p< 0.001), sepsis (4.7% vs 3%,p< 0.001), AKI (25.6% vs. 16.9%,p< 0.001), ICU admission (8.2% vs. 3%, p< 0.001), deep vein thrombosis (5.4% vs. 2.4%,p< 0.001), pulmonary embolism (1.6 vs 0.7%,p< 0.001) and pancreatic cancer (3% vs. 1.2%, < 0.001). After adjusting for confounding factors, patients with sarcopenia had higher odds of in-hospital mortality (aOR-3.29, 95% CI-3.06-3.54, p< 0.001), sepsis (aOR-1.58, 95% CI-1.49-1.69,p< 0.001), AKI (aOR-1.46, 95% CI-1.42-.1.51,p< 0.001), ICU admission (aOR- 2.6, 95% CI – 2.47-2.74, p< 0.001), deep vein thrombosis (aOR-2.11, 95% CI-1.81-2.16,p< 0.001), pulmonary embolism (aOR-2.19, 95% CI-1.96-2.45,p< 0.001), and pancreatic cancer (aOR- 1.98, 95% CI – 1.81-2.16, p< 0.001). Patients with sarcopenia also had a statistically significant longer length of stay (Adj. coefficient 3.87, 95% CI-3.75-4,p< 0.001) and higher hospitalization charges (Adj. coefficient 40285.15, 95% CI-38,072.5-48,497.75,p< 0.001).

Discussion: Our study reports that patients with sarcopenia are at higher risk of worse outcomes compared to those without sarcopenia. Physicians should be aware of these findings, and early interventions aimed at improving the nutritional status in this high-risk population are warranted.



Disclosures:


Anmol Singh, MBBS¹, Sahiljot Bhupal, MBBS², Carol Singh, MBBS³, Vikash Kumar, MD⁴, Ritika Dhruve, MBBS⁵, Aalam Sohal, MD⁶, Juliana Yang, MD⁷. P0052 - Sarcopenia is Associated With Increased Mortality And Resource Utilization in Patients With Chronic Pancreatitis: Analysis of National Inpatient Sample 2016-2020, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.