P0060 - Rising Mortality and Disability From Gallbladder and Biliary Disease Globally and in the United States of America: Insights From a Global Burden of Disease Study

Muhammad Ali Khaqan, MD¹, Muhammad Shahzil, MD², Laiba Sarfraz, MBBS³, Muhammad Tayyab Anwar, MD¹, Aleeza Habib, MBBS³, Ayesha Sabir, MBBS³, Muhammad Ammar Ur Rahman, MBBS³, Jawad Ahmed, MBBS³, Luqman Munir, MBBS³, Amna Khalid, MBBS^3
1John H. Stroger, Jr. Hospital of Cook County, Chicago, IL; ²Penn State Health Milton S. Hershey Medical Center, Hershey, PA; ³King Edward Medical University, Lahore, Punjab, Pakistan

Introduction: Biliary disease includes the pathologies involving gall bladder and biliary duct system involved in its transportation. Bile is synthesized in the liver then is stored in gall bladder and finally is transported through bile ducts for emulsification of fats.

Methods: This study examines trends in mortality and disability-adjusted life years (DALYs) due to gall bladder and biliary disease from 1999 to 2021. By analyzing age-adjusted mortality rates (AAMRs) and DALYs, we compare the disease's impact and prevalence in the USA with global trends, addressing variations in disease progression and survival outcomes.



We analyzed data on Disability-Adjusted Life Years (DALYs), deaths (AAMRs), and prevalence of gall bladder and biliary disease in the United States from 1990 to 2021, with gender-specific insights. This information, sourced from the Global Burden of Diseases database, includes age-adjusted rates per 100,000 people and annual percent change (APC) with a 95% confidence interval. Trends over time were assessed using the Joinpoint Regression Program (version 5.0.2).

Results: From 1990 to 2018, there has been a moderate increase in Disability-Adjusted Life Years (DALYs) due to biliary tract disease, with an average annual percent change (AAPC) of 0.27%. Although DALYs decreased in 2007 in the USA, they gradually increased afterward, with an overall AAPC of -0.2431%. However, trends in overall mortality rates in the USA show a gradual increase with an AAPC of 0.53%, compared to the global mortality rate with an AAPC of -0.34%. The prevalence of biliary disease increased (APC 1.58%) from 1990 to 2021. The disparity in mortality, DALYs, and prevalence between different genders shows that females are more affected. However, the AAPC for males vs. females is 0.73 and 0.29, respectively, indicating a trend toward increased risk for males in recent years.

Discussion: Biliary disease is a chronic yet preventable condition affecting many Americans, as evidenced by its high mortality and prevalence rates. The significant increase after 2007 necessitates urgent attention from the healthcare system to reduce the current mortality rate associated with this disease. Therefore, it is imperative to issue guidelines for lifestyle modifications, particularly for geriatric patients, and to implement measures aimed at decreasing disease mortality and complications.



Disclosures:


Muhammad Ali Khaqan, MD¹, Muhammad Shahzil, MD², Laiba Sarfraz, MBBS³, Muhammad Tayyab Anwar, MD¹, Aleeza Habib, MBBS³, Ayesha Sabir, MBBS³, Muhammad Ammar Ur Rahman, MBBS³, Jawad Ahmed, MBBS³, Luqman Munir, MBBS³, Amna Khalid, MBBS³. P0060 - Rising Mortality and Disability From Gallbladder and Biliary Disease Globally and in the United States of America: Insights From a Global Burden of Disease Study, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.