Evelyn Calderon Martinez, MD1, Devindra Chamlagai, MD1, Christina Tache, MD1, Gabriela Calderon, MD1, Adalberto Guzman, MD2, Christian Zevallos-Delgado, MS3, Maria Joseph, MD1 1UPMC Central PA, Harrisburg, PA; 2University of Arkansas for Medical Sciences, Harrisburg, PA; 3University of Houston, Houston, TX
Introduction: Acute pancreatitis (AP) is a severe abdominal disorder characterized by sudden onset, rapid progression, and high mortality. Currently, we use the Acute Physiology and Chronic Health Evaluation II Score (APACHE II) and Ranson's Criteria to determine the severity of AP. However, these tools require multiple factors. Thus, a more straightforward and quick option is needed for predicting disease severity. The lymphocytes-neutrophil ratio (LNR), platelet-to-albumin ratio (PAR), and other serum biomarker ratios represent easily reproducible markers that may predict the outcomes of various diseases. We aim to assess the prognostic value of these ratios in AP.
Methods: This study was reviewed and approved by the University of Pittsburgh Medical Center of Central Pennsylvania Review Board. Using Epic’s SlicerDicer function, patients with acute pancreatitis admitted were identified. Those with incomplete information or duplicated were excluded obtaining a total of 78 patients. We reported continuous variables as mean (range) and categorical variables as number (percent). We used a cut-off determined by using a receiver operating characteristic (ROC) curve. We used Student’s t-test to analyze between-group differences for the continuous variables.
Results: Seventy-eight patients were admitted with acute pancreatitis. Regarding etiology, 30% were alcohol-related, 10% were gallstone-related, and no clear cause was found in 38.4% of patients. Other demographic information can be found in Table 1. Eight patients (10.3%) died, 5 were readmitted, and 10 patients (12.8%) needed ICU admission. ROC analysis and Youden’s J-point suggested that the optimal cut-off values of RDW/Albumin ratio and Hemoglobin/RDW ratio showed significant differences in mortality of patients admitted with acute pancreatitis. For the RDW/Albumin ratio, the cut-off value was 0.5214 (AUC: 0.713, p=0.05) with a sensitivity of 75% and specificity of 77.14%. And in the case of the Hemoglobin/RDW ratio, the cut-off values were 0.4321 (AUC: 0.691, p=0.019) with a sensitivity of 87.5% and specificity of 55.71%.
Discussion: RDW/Albumin and Hemoglobin/RDW ratios showed a significant difference in predicting mortality in patients admitted with acute pancreatitis
Figure: ROC analysis representing the prognostic value for prognosis for RDW/Albumin ratio and Hemoglobin/RDW ratio in patients admitted with acute pancreatitis.
Note: The table for this abstract can be viewed in the ePoster Gallery section of the ACG 2024 ePoster Site or in The American Journal of Gastroenterology's abstract supplement issue, both of which will be available starting October 27, 2024.
Disclosures:
Evelyn Calderon Martinez indicated no relevant financial relationships.
Devindra Chamlagai indicated no relevant financial relationships.
Christina Tache indicated no relevant financial relationships.
Gabriela Calderon indicated no relevant financial relationships.
Adalberto Guzman indicated no relevant financial relationships.
Christian Zevallos-Delgado indicated no relevant financial relationships.
Maria Joseph indicated no relevant financial relationships.
Evelyn Calderon Martinez, MD1, Devindra Chamlagai, MD1, Christina Tache, MD1, Gabriela Calderon, MD1, Adalberto Guzman, MD2, Christian Zevallos-Delgado, MS3, Maria Joseph, MD1. P0002 - Serum Biomarkers Ratios as Prognostic Factors in Acute Pancreatitis, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.
