P3205 - Celiac Disease: Extraintestinal Presentations Data From Developing Country

Talal Khurshid, MBBS¹, Fareed Muslim, MD², Ali Sufyan, MBBS³, Madeha Irfan, MBBS^4
1SZABMU, New, Islamabad, Pakistan; ²Allama Iqbal Medical College, Islamabad, Islamabad, Pakistan; ³SZABMU, Islamabad, Islamabad, Pakistan; ⁴Islam Medical and Dental College, Islamabad, Islamabad, Pakistan

Introduction: Celiac disease (CD) is an immune mediated bowel disorder characterized by sensitivity to gluten. Patients generally present with diarrhea however presentations and features can vary. Diagnosis of celiac disease is made by history and clinical presentation compatible with CD, serological screening compatible with CD, histological findings, compatible with CD, obvious clinical and serological response to a gluten-free diet, and exclusion of other clinical conditions mimicking CD. Extra Intestinal manifestations in Celiac population in Pakistan in not well studied.

Methods: This is a cross sectional study conducted at a public sector tertiary care setup of Islamabad. Patients who were diagnosed cases of Celiac disease on the basis of serology and/or histopathology were interviewed via a structured questionnaire via non probability consecutive sampling technique. Patient’s age, gender, age of diagnosis, diagnostic modality, extra intestinal features, gluten free diet status and response and challenges in gluten free diet were recorded while ensuring patient anonymity. Data was entered and statistical analysis was performed via IBM SPSS version 25

Results: A total of 340 patients were enrolled in present study. Mean age of participants was 21.07 ± 12.99 years with predominantly female patients (62.9%). Most common Extra-intestinal feature was Anemia reported by 51.5% of patients (Figure I). Dermatological features and Malaise were significantly more common in patients with higher age. Anemia was significantly more likely in Female patients. Patients with stunted growth is significantly more likely to feel socially left out.

Discussion: Celiac Disease can present with multiple extra intestinal features. Most common feature was Anemia. Extraintestinal manifestations may have gender predisposition as Anemia is significantly more likely in female gender and age as Dermatological features were more likely in relatively older patients.



Disclosures:


Talal Khurshid, MBBS¹, Fareed Muslim, MD², Ali Sufyan, MBBS³, Madeha Irfan, MBBS⁴. P3205 - Celiac Disease: Extraintestinal Presentations Data From Developing Country, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.