John H. Stroger, Jr. Hospital of Cook County Chicago, IL
Alejandro J. Nieto Dominguez, MD, Sarah Eichinger, DO John H. Stroger, Jr. Hospital of Cook County, Chicago, IL
Introduction: Gastroparesis, characterized by delayed gastric emptying in the absence of mechanical obstruction, is a chronic and debilitating gastrointestinal disorder. The etiology is multifactorial, with diabetes mellitus being a common underlying cause. However, there is evidence that other systemic conditions, such as hypothyroidism, may also play a role in its pathogenesis. Hypothyroidism, a common endocrine disorder, can affect gastrointestinal motility and potentially exacerbate or contribute to the development of gastroparesis. This nationwide analysis aims to explore the association between hypothyroidism and gastroparesis in hospitalized patients, seeking to provide a deeper understanding of these interconnected conditions and the implications for patient care.
Methods: Our study utilized data from the National Inpatient Sample, a comprehensive US database of inpatient hospital stays, from 2016 to 2019. We specifically focused on patients admitted with gastroparesis and evaluated the relationship with hypothyroidism. For our statistical analysis, we used STATA version 18.
Results: The presence of gastroparesis was associated with increased odds of developing hypothyroidism, with an odds ratio (OR) of 1.3173 (95% CI: 1.2351 to 1.4050. This multivariate logistic regression analysis was adjusted for several confounders including age, gender, race, Charlson Comorbidity Index, insurance status, income, hospital region, hospital bed size, hospital teaching status and several comorbidities including diabetes mellitus, hypertension, chronic kidney disease, dyslipidemia, smoking history, and coronary artery disease.
Demographic characteristics are shown in Figure 1.
Discussion: In hypothyroidism, the decreased levels of thyroid hormones lead to a generalized slowing of metabolic processes, including those governing gastrointestinal motility. This can result in delayed gastric emptying and subsequent symptoms of gastroparesis.
Our study shows a significant association between these two entities underscoring the importance on screening all patients with gastroparesis for hypothyroidism.
Figure: Demographic characteristics of patients admitted with gastroparesis with and without co-morbid hypothyroidism.
Disclosures:
Alejandro Nieto Dominguez indicated no relevant financial relationships.
Sarah Eichinger indicated no relevant financial relationships.
Alejandro J. Nieto Dominguez, MD, Sarah Eichinger, DO. P3336 - Hypothyroidism in Patients With Gastroparesis: A Nationwide Analysis, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.
