P3465 - Pancreatic Cyst Prevalence in Younger Adults: A Single Center Observational Analysis

Alexandra Leto, MD, Sarah Coughlin, MD, Nuzhat Ahmad, MD
University of Pennsylvania, Philadelphia, PA

Introduction: The prevalence of pancreatic cystic lesions has been demonstrated to increase with age ( >50). This phenomenon has been attributed in part to increased utilization of cross-sectional imaging over time. Little research has been done to evaluate how increased utilization of abdominal imaging has impacted the prevalence of pancreatic cystic lesions in younger adults. We hypothesize that the prevalence of pancreatic cystic lesions has increased in adults < 50 years of age over time.

Methods: This exploratory retrospective, single tertiary care center cohort study evaluated patients with pancreatic cysts identified on computed tomography (CT) and magnetic resonance imaging (MRI) between January 1996 - December 2005. Data was extracted from a radiology database and the electronic medical record. We defined “pancreatic cyst” as both neoplastic and non-neoplastic lesions in all patients, with subcategories to indicate if evidence of pseudocysts or Von Hippel-Lindau (VHL) disease was present. Primary variables of interest included age at diagnosis and frequency of new pancreatic cyst diagnosis by year.

Results: A total of 122 patients (mean age 40, 61% female) met inclusion criteria, with 57% having CT as the imaging modality for their index scan. 14.7% (18) of patients were 20-29 years of age at the time of diagnosis, 28.7% (35) ages 30-39, and 56.6% (69) ages 40-49. Of these patients, 7% (8) were identified to have VHL disease and 13% (16) were found to have pancreatic cysts consistent with the diagnosis of pseudocyst. There was a positive association observed between the frequency of new diagnoses of pancreatic cysts in younger adults under the age of 50 and year (R² 0.95, p= 0.00).

Discussion: This exploratory retrospective cohort study supports an increase in the prevalence of pancreatic cysts detected in patients under the age of 50 over this 10-year period. The data also supports greater prevalence of pancreatic cyst diagnoses with increasing age even among patients < 50 years old. Future efforts are necessary and warranted to determine if these findings have persisted over subsequent decades, and to elucidate the clinical relevance of the pancreatic cystic lesions identified in patients < 50 years of age.


Disclosures:


Alexandra Leto, MD, Sarah Coughlin, MD, Nuzhat Ahmad, MD. P3465 - Pancreatic Cyst Prevalence in Younger Adults: A Single Center Observational Analysis, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.