University of Mississippi Medical Center Madison, MS
Yousaf Zafar, MD1, Syed Zaeem Ahmed, 2, Muhammad Umer Sohail, 2, Muhammad Saad, 2, Muhammad Ovais Sohail, 3, Arsalan Zafar Iqbal, 1, Shahryar Khan, MD4, Laila Manzoor, 1, Jan Petrasek, MD, PhD5 1University of Mississippi Medical Center, Madison, MS; 2Dow University of Health Sciences, Madison, MS; 3Conemaugh Memorial Medical Center, Karachi, Sindh, Pakistan; 4University of Kansas, Overland Park, KS; 5Texas Liver Institute, San Antonio, TX
Introduction: It is known that the incidence and mortality linked to colorectal cancer (CRC) are higher in Mississippi compared to other states in the United States (US). This study examines the temporal trends in CRC mortality between Mississippi and other US states from 1999–2020.
Methods: The Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) Multiple Causes of Death database was used to analyze CRC mortality. Age-adjusted mortality rates (AAMR) and crude mortality rates (CMR) per 100,000 people were calculated, and Joinpoint regression was employed to calculate the annual percent change (APC). APC were used to assess the trends in overall, sex, age (middle-aged adult: 25–64; older adult: 65+), and geographic region mortality rates.
Results: For Mississippi, CRC-associated AAMR decreased from 25.44 in 1999 to 21.08 in 2020 per 100,000 persons. A similar trend was observed in other states, with values decreasing from 24.72 in 1999 to 14.80 in 2020. However, the magnitude of the decrease in AAMR varied. For Mississippi, the AAMR initially showed a steady decrease from 1999 to 2018 (APC: -1.50; 95% CI [-3.83, 3.56]), which was followed by an increase up until 2020 (APC: 3.27; 95% CI [-1.69, 6.80]). For other states, there was initially a decrease in AAMR up until 2013 (APC: -2.99; 95% CI [-3.18, -2.85]), and then a further decrease up until 2020 (APC: -1.69; 95% CI [-2.08, -0.97]). Males in Mississippi had higher AAMRs (28.61) than males in other states (22.31). This trend was mirrored in females in Mississippi (AAMR: 18.69) compared to females in other states (15.45). Middle-aged (MA) adults in Mississippi had a higher overall CMR (13.83) compared to MA adults in other states (CMR: 8.83). Similarly, older adults in Mississippi demonstrated a higher CMR (124.14) than in other states (109.34). Geographic disparities also exist, with metropolitan areas within Mississippi having a higher AAMR (21.65) than metropolitan areas in other states (AAMR: 17.96). A similar trend is seen in non-metropolitan areas in Mississippi (AAMR: 23.86) and other states (20.65).
Discussion: Our findings reveal that there is a disproportionate burden of CRC in Mississippi as compared to other states. Further research is required to comprehend these trends and develop effective preventive strategies.
Figure: Colorectal cancer mortality in Mississippi vs other states in the U.S stratified (A) Overall and sex (B) Age (C) Geographic region
Disclosures:
Yousaf Zafar indicated no relevant financial relationships.
Syed Zaeem Ahmed indicated no relevant financial relationships.
Muhammad Umer Sohail indicated no relevant financial relationships.
Muhammad Saad indicated no relevant financial relationships.
Muhammad Ovais Sohail indicated no relevant financial relationships.
Arsalan Zafar Iqbal indicated no relevant financial relationships.
Shahryar Khan indicated no relevant financial relationships.
Laila Manzoor indicated no relevant financial relationships.
Jan Petrasek indicated no relevant financial relationships.
Yousaf Zafar, MD1, Syed Zaeem Ahmed, 2, Muhammad Umer Sohail, 2, Muhammad Saad, 2, Muhammad Ovais Sohail, 3, Arsalan Zafar Iqbal, 1, Shahryar Khan, MD4, Laila Manzoor, 1, Jan Petrasek, MD, PhD5. P3637 - Trends in Colorectal Cancer Mortality in Mississippi Compared to Other States in the United States From 1999 to 2020, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.
