University of Texas Rio Grande Valley Edinburg, TX
Award: Presidential Poster Award
Kashif Ali, MD1, Iqra Maryam, MBBS2, Usama B. Shabbir, MD3, Alamdar Hussain, MD4, Muhammad Hussnain Cheema, MD4, Muhammad Hassan Cheema, MD4, Noor Fatima, MBBS4, Aeman Zafar, MBBS4, Hamza Saleem, MD4, Ghulam Mustafa, MBBS5 1University of Texas Rio Grande Valley, Edinburg, TX; 2Fatima Jinnah Medical University, Multan, Punjab, Pakistan; 3Services Institute of Medical Sciences, Lahore, Punjab, Pakistan; 4Nishtar Medical University, Multan, Punjab, Pakistan; 5Dow University of Health Sciences, Karachi, Sindh, Pakistan
Introduction: Endoscopic placement of biliary stents is a common approach for managing benign biliary strictures (BBS). Nonetheless, traditional metal and plastic stents have notable drawbacks. Ensuring long-term efficacy, mitigating fibrosis, and ensuring compatibility with the body are pivotal considerations for effectively utilizing stents in BBS treatment. Our study sought to evaluate both the degradation process and the therapeutic impact of drug-eluting biodegradable biliary stents (DBBS).
Methods: We created a biodegradable stent (DBS) infused with dexamethasone, featuring a durable sheath/core design. This stent exhibited excellent mechanical strength and consistently released dexamethasone, sustaining its efficacy within a BBS duct for a period of 12 weeks.
Results: The deployment of our DBS not only enlarged areas affected by BBS but also facilitated the healing of secondary ulcers by reducing fibrosis. Sixteen weeks post-insertion, the BBS areas showed complete improvement, and the DBS had degraded and completely dissolved without the need for additional intervention for stent removal.
Discussion: Our study concluded that DBBS retained their initial shape and radial strength over an extended period while exhibiting significant therapeutic benefits.
Disclosures:
Kashif Ali indicated no relevant financial relationships.
Iqra Maryam indicated no relevant financial relationships.
Usama Shabbir indicated no relevant financial relationships.
Alamdar Hussain indicated no relevant financial relationships.
Muhammad Hussnain Cheema indicated no relevant financial relationships.
Muhammad Hassan Cheema indicated no relevant financial relationships.
Noor Fatima indicated no relevant financial relationships.
Aeman Zafar indicated no relevant financial relationships.
Hamza Saleem indicated no relevant financial relationships.
Ghulam Mustafa indicated no relevant financial relationships.
Kashif Ali, MD1, Iqra Maryam, MBBS2, Usama B. Shabbir, MD3, Alamdar Hussain, MD4, Muhammad Hussnain Cheema, MD4, Muhammad Hassan Cheema, MD4, Noor Fatima, MBBS4, Aeman Zafar, MBBS4, Hamza Saleem, MD4, Ghulam Mustafa, MBBS5. P3432 - Dexamethasone-Eluting and Self-Expanding Biodegradable Stents Effectively Reduce Fibrosis in Cases of Biliary Stricture, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.
