Momin Samad, MD1, Ciara White, 2, Sheema Rehman, DO3, Nina Brahmbhatt, 2, Muhammad Memon, MD3, Rami M. Youssef, MD3, Abdulmalik Saleem, MD4, Humza Ali, 5, Syed-Mohammed Jafri, MD4 1Henry Ford Hospital, Rochester Hills, MI; 2Wayne State University, Detroit, MI; 3Henry Ford Hospital, Detroit, MI; 4Henry Ford Health, Detroit, MI; 5Touro College of Osteopathic Medicine, Troy, MI
Introduction: Immunosuppression poses a potential risk for infectious complications following surgery. While most elective and some non-elective orthopedic procedures are generally safe, their post operative infectious complications in liver transplant patients are understudied. Our purpose of this study is to evaluate risk factors for development of short-term infectious complications following elective and non-elective orthopedic surgeries in liver transplant patients.
Methods: The study design is a retrospective cross-sectional study. Data extraction using SlicerDicer was used to identify patients who underwent liver transplantation and elective and non-elective orthopedic surgeries following transplantation from 2013-2022. Data collected included demographics, number of months following transplant, type of orthopedic surgery, and immunosuppression at time of orthopedic surgery. Primary outcomes included infection within 30 days of orthopedic surgery and death within three months.
Results: A total of 87 patients were identified. The average patient age was 67.5 years at the time of orthopedic surgery. The mean length of time from transplantation to orthopedic surgery was 87 months. Elective surgeries comprised more of the population with 26 undergoing total knee arthroplasty (30%) and 19 undergoing total hip arthroplasty (22%). Non-elective surgeries included open reduction internal fixation (ORIF) and closed reduction internal fixation (CRIF) following acute fracture, comprising of 16 patients (18%). Infections within 30 days were identified in four patients, two of which underwent total hip arthroplasty. However, there is no significant association between infections within 30 days and type of surgery or immunosuppression at the time of surgery. Additionally, there were no patient deaths that resulted from infection.
Discussion: We evaluated outcomes following orthopedic surgeries in patients following liver transplantation. Our results support the safety and efficacy of these surgeries following liver transplantation.
Disclosures:
Momin Samad indicated no relevant financial relationships.
Ciara White indicated no relevant financial relationships.
Sheema Rehman indicated no relevant financial relationships.
Nina Brahmbhatt indicated no relevant financial relationships.
Muhammad Memon indicated no relevant financial relationships.
Rami Youssef indicated no relevant financial relationships.
Abdulmalik Saleem indicated no relevant financial relationships.
Humza Ali indicated no relevant financial relationships.
