P2579 - Temporal Trends in the Incidence of Inflammatory Bowel Disease in the United States for the Past 3 Decades

Ahmed A. Abdulelah, MD¹, Lina AlQirem, MD², Zaid A. Abdulelah, MD³, Mohammad Alqaisieh, MD⁴, Dua' Al-Husni, MD⁵, Yazan Gharaibeh, MD⁶, Amer Khatib, MD^7
1University of Edinburgh, Edinburgh, Scotland, United Kingdom; ²University of Arkansas for Medical Sciences, Little Rock, AR; ³Royal Papworth Hospital, Cambridge, England, United Kingdom; ⁴Hamilton Medical Center, Dalton, GA; ⁵Cleveland Clinic Foundation, Cleveland, OH; ⁶Royal Free London NHS Trust, London, England, United Kingdom; ⁷University of Jordan, Amman, 'Amman, Jordan

Introduction: Inflammatory bowel disease (IBD) is among the leading gastrointestinal diseases in terms of the resultant socioeconomic and health burden due to the resultant morbidity, impaired quality of life, and associated risk of malignancy. Accordingly, thorough evaluation of the temporal trends in the incidence of IBD is of paramount significance as it enables risk stratification and facilities health policy interventions and modifications.

Methods: The temporal trends of the incidence of IBD in the United States over the past 30 years were firstly evaluated by retrieving the relevant data from the Global Burden of Diseases 2019 database. The Annual Percentage Change (APC) and the Average Annual Percentage Change (AAPC) stratified by age and gender were calculated using Joinpoint Analysis software. Given the bimodal incidence pattern of IBD, the age groups of 15-19 years old, 20-24 years old, 25-29 years old, 60-64 years old, and 65-69 years old were evaluated when the incidence was stratified by age.

Results: Over the period of 1990-2019, a total of 1,739,726 IBD cases were reported in the United States with equal gender distribution. Stratification by age demonstrated a statistically significant increase in IBD incidence across all of the evaluated age groups. Notably, the highest increment in incidence was observed among individuals aged 60-64 years old with an AAPC of 0.84 (95%CI 0.83 to 0.86; p< 0.001), followed by individuals aged 65-69 years old with an AAPC of 0.82 (95%CI 0.80 to 0.83; p< 0.001). Among the younger age groups, the highest increase in IBD incidence was noted in the 25-29 years old age group with an AAPC of 0.46 (95%CI 0.40 to 0.51; p< 0.001) followed by the 20-24 years old age group (AAPC 0.29; 95%CI 0.22 to 0.36; p< 0.001). The least increment in IBD incidence was observed in the 15-19 years old age group with an AAPC of 0.22 (95%CI 0.15 to 0.29; p< 0.001). Gender stratification of IBD incidence revealed a statistically significant incline in incidence among both males and females, with females demonstrating a slightly higher incline (AAPC 1.27; 95%CI 1.24 to 1.30; p< 0.001). Whereas males had an AAPC of 1.10 (95%CI 1.07 to 1.10; p< 0.001).

Discussion: During the past 3 decades, the incidence of IBD in the United States witnessed a significant incline among males and females and across both bimodal age groups. However, the most significant increment in incidence was among the older age groups, thus mandating prompt recognition and intervention.


Disclosures:


Ahmed A. Abdulelah, MD¹, Lina AlQirem, MD², Zaid A. Abdulelah, MD³, Mohammad Alqaisieh, MD⁴, Dua' Al-Husni, MD⁵, Yazan Gharaibeh, MD⁶, Amer Khatib, MD⁷. P2579 - Temporal Trends in the Incidence of Inflammatory Bowel Disease in the United States for the Past 3 Decades, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.