P2455 - Cross-State Comparative Assessment of Burden of Vascular Intestinal Disorders and Its Trend in the United States From 1990-2021: A Benchmarking Secondary Analysis From the Global Burden of Disease Study 2021

Venkata Ramana Katikala, MBBS¹, George Mathew Mukalil, MD², Bhargav Koyani, MD³, SIRI VUMMANENI, MBBS⁴, Lalitkumar Patel, MBBS⁵, Aditya Ahuja, MBBS⁶, Gunjan Kochhar, MBBS⁷, Cleris Christian, MD⁸, Rutvik Raval, MBBS⁹, Shamitha Hejmadi, MBBS⁹, Lovekumar Vala, MBBS¹⁰, Rani Ratheesh, MD¹¹, Hardik Dineshbhai. Desai, MBBS^12
1Konaseema Institute of Medical Sciences and Research Foundation, McKinney, TX; ²Central Michigan University, Saginaw, MI; ³Saint Francis Hospital, Evanston, Evanston, IL; ⁴Sri Devaraj Urs Medical College, Kolar, Karnataka, India; ⁵Suburban Medical Center, Schaumburg, IL; ⁶Shrimann Hospital, Jalandhar, Punjab, India; ⁷Punjab Institute of Medical Sciences, Jalandhar, Punjab, India; ⁸Central Michigan University College of Medicine, Saginaw, MI; ⁹B.J. Medical College, Ahmedabad, Gujarat, India; ¹⁰Shantabaa Medical College and General Hospital, Amreli, Gujarat, India; ¹¹Dr. MGR Medical University, Chennai, Tamil Nadu, India; ¹²Gujarat Adani Institute of Medical Sciences, Ahmedabad, Gujarat, India

Introduction: Vascular intestinal disorders (VID), such as mesenteric ischemia and ischemic colitis, are significant health concerns in the United States, particularly among the elderly due to common vascular risk factors like atherosclerosis. The economic and quality of life impacts are profound, necessitating improved preventive and management strategies as the U.S. population continues to age. This study is the first to estimate the cross-state burden of VID in the US, encompassing the initial two years of the COVID-19 pandemic.

Methods: Using global burden of disease 2021 methodologies, we estimated incidence, prevalence, deaths, disability-adjusted life years (DALYs) due to VID by age, sex, year and location across the US from 1990-2021. Non-fatal health outcomes were estimated using DISMOD MR 2.1, a meta regression tool, while fatal health outcome were estimated using cause of death ensemble mode (CODEm).

Results: The total prevalence count of VID increased from 20,096 (95% uncertainty interval: 18,491-21,795) in 1990 to 27,547 (25,782-29,403) in 2021. The total percentage change (TPC) in incidence count rose by 46%, with deaths increasing by 16% and DALYs by 21% from 1990 to 2021. In terms of the age-standardized incidence rate (ASIR), the District of Columbia was the only state to observe a TPC increase of 2%, while all other states saw decreases. Age-wise, the 20-54 age group saw a 19% rise in TPC for incidence, followed by a 53% increase in the 55+ age group from 1990 to 2021. For deaths, the 20-54 age group experienced a 31% increase, while the 55+ age group saw a 15% increase from 1990 to 2021. Regarding gender, males exhibited a higher increase in burden compared to females, with a TPC in incidence of 52% for males versus 42% for females, in deaths 26% versus 10%, and in DALYs 27% versus 17% from 1990 to 2021.

Discussion: Death due to VID accounted for 7.83% of all non-malignant digestive disease related causalities in 2021. This study underscores a significant rise in VID in the U.S., particularly among males and the 20-54 age group, with notable geographic variations. From a public health perspective, these findings highlight the need for preventive strategies and targeted awareness campaigns.



Disclosures:


Venkata Ramana Katikala, MBBS¹, George Mathew Mukalil, MD², Bhargav Koyani, MD³, SIRI VUMMANENI, MBBS⁴, Lalitkumar Patel, MBBS⁵, Aditya Ahuja, MBBS⁶, Gunjan Kochhar, MBBS⁷, Cleris Christian, MD⁸, Rutvik Raval, MBBS⁹, Shamitha Hejmadi, MBBS⁹, Lovekumar Vala, MBBS¹⁰, Rani Ratheesh, MD¹¹, Hardik Dineshbhai. Desai, MBBS¹². P2455 - Cross-State Comparative Assessment of Burden of Vascular Intestinal Disorders and Its Trend in the United States From 1990-2021: A Benchmarking Secondary Analysis From the Global Burden of Disease Study 2021, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.