P0847 - Temporal Trends and Racial Disparities in Inflammatory Bowel Disease-Related Mortality in the United States and Texas: 1999-2020 CDC Wonder Insights

Sidra Naz, MD, MPH¹, David M.. Richards, MD¹, Mazen Alasadi, MD^2
1University of Texas MD Anderson Cancer Center, Houston, TX; ²The University of Texas MD Anderson Cancer Center, Houston, TX

Introduction: There is no consensus on whether inflammatory bowel disease (IBD) leads to an increase in mortality. We aimed to assess the trends of IBD-related mortality in the US vs Texas and identify associated sociodemographic factors in patients with inflammatory bowel disease to evaluate public health efforts and inform prevention and treatment strategies.



Methods: Death certificates from the Centres for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research database (CDC's WONDER) were examined from 1999 to 2020 for IBD-related mortality (ICD-10 code K 50.9 and K51.9) in adults aged ≥25 years. Age-adjusted mortality rates (AAMRs) per 100,000 persons and annual percent change (APC) were calculated and stratified by year, sex, and race/ethnicity.

Results: The AAMR of IBD-related mortality in the US declined from 1.3 in 1999 to 1.2 in 2018 (APC: -026%, 95% CI: 0.17% to -0.87%), after which it increased to 1.6 in 2020 (APC: 14.7%; 95% CI: 19.27% to 4.38%). In Texas, the AAMR of IBD-related mortality decreased from 1.3 in 1999 to 0.8 in 2001 (APC: -12.86%; 95% CI: 2.15% to -21.51%) after which it increased to 1.2 in 2020 (APC: 1.03%; 95% CI: 9.69% to -13.15%). The AAMR in the US men declined from 1.4 in 1999 to 1.3 in 2018 (APC: -0.12%; 95% CI: 0.12% to -0.42%) after which it increased to 1.6 in 2020 (APC: 11.1%; 95% CI: 14.7% to 4.9%). The AAMR in US women decreased from 1.2 in 1999 to 1.1 in 2018 ((APC: -0.13%; 95% CI: 0.14% to -0.46%) after which it increased to 1.5 in 2020 (APC: 13.34%; 95% CI: 16.30% to 7.38%). Non-Hispanic (NH) White population had the greatest AAMR (1.9), followed by NH American Indian or Alaska Native (1.4), and NH Black or African American (AA) (1.1) adults.



Discussion: IBD-related mortality has risen in recent years both in Texas and the US. Men had higher AAMR compared to women. Variation in AAMR was seen across ethnicities with the NH White population having higher AAMR compared to American Indian or Alaska Native, and Black or AA populations.



Disclosures:


Sidra Naz, MD, MPH¹, David M.. Richards, MD¹, Mazen Alasadi, MD². P0847 - Temporal Trends and Racial Disparities in Inflammatory Bowel Disease-Related Mortality in the United States and Texas: 1999-2020 CDC Wonder Insights, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.