P0619 - Update on self reported Gastrointestinal Symptoms and Glucose Breath Test Results in Small Intestinal Bacterial Overgrowth: A retrospective Analysis

Sahla Hammad, MD¹, Jonathan D. Dvorak, MD², Jason Baker, ³, Jennifer Wellington, DO, MSc¹, Satish S. C.. Rao, MD, PhD⁴, Baharak Moshiree, MD^5
1Atrium Health, Charlotte, NC; ²Carolinas Medical Center, Charlotte, NC; ³Anxrobotics, Foley, AL; ⁴Medical College of Georgia, Augusta University, Augusta, GA; ⁵Advocate Health Wake Forest Medical University, Charlotte, NC

Introduction: Small Intestinal Bacterial Overgrowth (SIBO) is diagnosed using Glucose Hydrogen Breath Testing (GBT). Gastrointestinal (GI) symptoms are poor predictors of GBT positivity. There is a paucity of literature on the predictive values of GI symptoms (sxs) and a positive GBT test. Our aim is To assess self-reported GI sx profiles in adults relative to their frequency, intensity, and duration and their correlation with GBT outcomes.

Methods: We retrospectively reviewed all adult patients (pts) presenting to a single medical center from 6/2022 – 09/2023 for GBT. All pts completed a GI questionnaire assessing 17 key sxs: regurgitation (RG), chest pain (CP), heartburn (HB), belch (BH), abdominal pain (AP), bloating (BT), gas (GS), nausea (NA), vomit (VT), abdominal cramps (AC), indigestion (ID), distension (DN), fullness (FL), early satiety (ES), diarrhea (DR), constipation (CN), and fatigue (FT). Sxs were measured by Frequency (None, < 1/week (wk), 1/wk, and ≥ 1/wk), Intensity (None, Mild, Moderate, Severe), and Duration (None, < 10 mins, 10 – 30 mins, and ≥ 30 mins). Sub-groups, GERD (RG+CP+HB), Dyspeptic (AP+BT+GS+NA+FL+ES), and IBS (AP+DR+CN) were constructed, assessing the mean summation scores for Frequency, Intensity, and Duration between negative and positive GBTs. Univariate analysis and logistic regression analysis were performed. A p-value of < 0.05 was considered statistically significant.

Results: N = 280 pts, mean age of 49.9 (SD = 16.9; Range: 18 – 85), 79.6% female, 78.6% Caucasian, and mean BMI of 26.2 (SD = 6.7) were analyzed. Significant differences and trends between negative and positive GBT groups: symptom frequency for IND (p = 0.05) and BL (p = 0.07); symptom intensity for VT (p = 0.09) and FL (p = 0.08); symptom duration for FL (p = 0.04), DR (p = 0.05), and VT (p = 0.09). Regression analysis depicted statistically significant relationship toward a positive GBT for an increasing Dyspeptic (p = 0.02; OR = 1.54; 95% CI: 1.09, 2.18) symptom intensity and Dyspeptic (p = 0.003; OR = 1.62; 95% CI: 1.18, 2.24) and IBS (p = 0.01; OR = 1.50; 95% CI: 1.10, 2.04) symptom duration controlling for age. Significant mean differences were seen between the Dyspeptic and IBS sub-groups relative t:o intensity, and duration mean summations scores. (see table)

Discussion: Our data analysis suggests that patients with longer duration of symptoms of dyspepsia, vomiting and IBS have a higher probability of positive GBT.


Disclosures:


Sahla Hammad, MD¹, Jonathan D. Dvorak, MD², Jason Baker, ³, Jennifer Wellington, DO, MSc¹, Satish S. C.. Rao, MD, PhD⁴, Baharak Moshiree, MD⁵. P0619 - Update on self reported Gastrointestinal Symptoms and Glucose Breath Test Results in Small Intestinal Bacterial Overgrowth: A retrospective Analysis, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.