P0072 - Systematic Review on the Prevalence of Pancreatitis as a Risk Factor to Pancreatic Cancer

Aaron Wen, BSc, SiYuan Pan, BSc, Kayla Dadgar, BSc, MD, Mohammed Yaghoobi, MD, MSc, FACG
Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada

Introduction: Pancreatic cancer (PC) is the third leading cause of cancer-related death in Canada. Limited information exists on the role of pancreatitis as a risk factor for PC. This systematic review aims to evaluate the relationship between a history of pancreatitis and the risk of developing PC.

Methods: We searched MEDLINE, EMBASE, CENTRAL, and Web of Science databases from inception to January 2024 for case-control studies reporting the prevalence of acute or chronic pancreatitis in adult patients with pancreatic cancers, including pancreatic ductal adenocarcinomas (PDACs), intraductal papillary mucinous neoplasms (IPMNs), and other subtypes. Screening, data extraction, and risk of bias assessments were performed independently by two authors.

Results: A total of 22 studies, encompassing 412,082 patients (48,603 PC cases and 363,479 controls), were included. The hazard ratio (HR) for developing PC in patients with a history of acute or chronic pancreatitis was 3.62 (95% CI:3.50-3.74), indicating a moderately increased risk. Studies focusing on PDAC patients (n=6) showed similar findings [HR 3.95 (95% CI:3.78-4.13)], whereas those examining IPMN patients (n=2) did not find a significant difference [HR 0.98 (95% CI:0.84-1.16)]. Twelve studies did not specify the PC type but also demonstrated a moderate association [HR 3.18(95% CI:3.00-3.37)]. These findings were consistent when stratified by age and gender. The overall risk of bias in the studies ranged from low to moderate, with most concerns related to the lack of confounder analysis and incomplete protocols.

Discussion: Current literature indicates a moderate association between pancreatitis and pancreatic cancer, consistent across gender and age subgroups. Further detailed reporting on the characteristics of acute pancreatitis, hospitalization rates, and comprehensive confounder analyses are necessary to strengthen the evidence base regarding this relationship.


Disclosures:


Aaron Wen, BSc, SiYuan Pan, BSc, Kayla Dadgar, BSc, MD, Mohammed Yaghoobi, MD, MSc, FACG. P0072 - Systematic Review on the Prevalence of Pancreatitis as a Risk Factor to Pancreatic Cancer, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.