P1740 - Impact of Cannabis Use Disorder on In-Hospital Outcomes of Pancreatitis: A Nationwide Inpatient Study Stratified by Etiology

Manasa Ginjupalli, MBBS, MD¹, Jayalekshmi Jayakumar, MBBS, MD², Hamsika Moparty, MD², Sweta Lohani, MBBS, MD³, Anuj R. Sharma, MBBS³, Naresh Kumar, MD², Yashwitha Sai Pulakurthi, MBBS, MD⁴, Vikash Kumar, MD⁵, Raissa Nana Sede Mbakop, MD², Madhavi Reddy, MD, FACG^3
1The Brooklyn Hospital Center, New York, NY; ²The Brooklyn Hospital Center, Brooklyn, NY; ³Brooklyn Hospital Center, Brooklyn, NY; ⁴Saint Michael's Medical Center, Newark, NJ; ⁵Creighton University School of Medicine, Brooklyn, NY

Introduction: The prevalence of cannabis use in the United States has been rising over the past decade, prompting active research into its healthcare effects. Case reports have linked cannabis use with acute pancreatitis, yet there remains limited data on its varied effects across different populations stratified by pancreatitis etiology. This study aims to assess the impact of cannabis use on hospitalizations for acute and chronic pancreatitis among cohorts with alcohol abuse and gallstones compared to those without either condition.

Methods: A retrospective analysis was performed using the National Inpatient Sample database 2016-2020 and ICD-10 codes were used to identify hospitalized adults with age > 18 years with diagnosis of alcohol abuse and gallstones. Additionally we identified a cohort of hospitalized individuals without alcohol abuse or gallstones. These cohorts were further stratified based on cannabis use. Prevalence of acute and chronic pancreatitis among different cohorts was compared and analyzed. Categorical variables were compared using chi-square test, and continuous variables were compared using t-test and results are reported along with their demographics and patient characteristics.

Results: Hospitalizations with alcohol abuse, gallstones and with neither of these two diagnoses were identified. Among these cohorts, prevalence of cannabis use was 10.9%, 1.56% and 2.31% respectively. Hospitalized adults using cannabis were found to be younger across all the three cohorts and were predominantly white. Majority of the population were from urban teaching hospitals. When the outcomes of acute and chronic pancreatitis were compared among different cohorts, we found that cannabis use was assosiated with significantly lower odds of developing both acute and chronic pancreatitis among hospitalized adults with alcohol abuse. Conversly, the odds were higher in other cohorts [Table 1].

Discussion: In our study, cannabis users with alcohol abuse had lower odds of developing acute and chronic pancreatitis. On contrary, cannabis users had higher odds of developing acute and chronic pancreatitis among adults with gallstones and those with neither alcohol abuse nor gallstones, although the reasons for this are unclear. Further prospective studies are required to identify this association especially considering the growing trend of using cannabis. Based on relevant data from further studies, tailored strategies to medically regulate cannabis use could be considered for better outcomes.


Disclosures:


Manasa Ginjupalli, MBBS, MD¹, Jayalekshmi Jayakumar, MBBS, MD², Hamsika Moparty, MD², Sweta Lohani, MBBS, MD³, Anuj R. Sharma, MBBS³, Naresh Kumar, MD², Yashwitha Sai Pulakurthi, MBBS, MD⁴, Vikash Kumar, MD⁵, Raissa Nana Sede Mbakop, MD², Madhavi Reddy, MD, FACG³. P1740 - Impact of Cannabis Use Disorder on In-Hospital Outcomes of Pancreatitis: A Nationwide Inpatient Study Stratified by Etiology, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.