P1745 - Gender and Racial Disparities in Pancreatic Cancer Incidence in Texas: A Statewide Population-Based Analysis

Ooreoluwa Fasola, MD
Texas Tech University Health Sciences Center - Permian Basin, Odessa, TX

Introduction: In the United States, pancreatic cancer is one of the few cancers with increasing incidence. Racial and gender disparities in the incidence of pancreatic cancer exist in the US. However, there is limited data regarding the racial and gender incidence trends in Texas. The aim is to assess the age-standardized incidence trends related to race and gender in Texas from 2000 – 2020.

Methods: Data on age-adjusted incidence rates by race and sex between 2000 – 2020 were extracted from the Texas Cancer Registry. Incidence rates were calculated per 100,000 population (age-adjusted to the 2000 U.S. standard population). The Joinpoint Regression Software was used to calculate annual percentage change (APC) and average APC (AAPC). P-value < 0.05 was considered statistically significant.

Results: A total of 58 288 patients were diagnosed with pancreatic cancer between 2000 - 2020 in Texas. Incidence rates were higher in males (13.8 per 100,000) than in females (10.6 per 100,000). Over the period, incidence rates increased significantly in females (AAPC 0.97, P< 0.01), whereas an increase in new pancreatic cases in males was not statistically significant (AAPC 0.32, P=0.09). Overall, incidence rates were consistently higher in non-Hispanic (NH) Blacks (16.2 per 100,000) compared to their NH Whites (11.9 per 100,000) and Hispanics (11.4 per 100,000). However, over the years, the incidence rates have been increasing significantly in white males (AAPC 0.58, P< 0.05), decreased in Hispanics (AAPC -0.13, P=0.71), and remained relatively stable in black males (AAPC 0.02, P=0.95). Incidence rates increased significantly in white females (AAPC 1.08, P< 0.01), Hispanic females (AAPC 0.88, P< 0.01), and black females (AAPC 0.56, P=0.11).

Discussion: The study shows that while pancreatic cancer incidence rates are higher in males and Blacks, incidence rates have been increasing among females and NH Whites from 2000 - 2020. Further research is needed to understand the underlying factors contributing to these trends.


Disclosures:


Ooreoluwa Fasola, MD. P1745 - Gender and Racial Disparities in Pancreatic Cancer Incidence in Texas: A Statewide Population-Based Analysis, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.