P1746 - Gender and Racial Disparities in Pancreatic Cancer Mortality in Texas: A Statewide Population-Based Study

Ooreoluwa Fasola, MD
Texas Tech University Health Sciences Center - Permian Basin, Odessa, TX

Introduction: Pancreatic cancer is the third leading cause of cancer-related death in the United States. Disparities in pancreatic cancer mortality exist but are understudied in Texas. The aim of this study was to assess the trends in pancreatic cancer mortality as it relates to gender and race/ethnicity.

Methods: Data on age-adjusted mortality rates by race and sex between 2000 – 2020 were extracted from the Texas Cancer Registry. Mortality rates were calculated per 100,000 population (age-adjusted to the 2000 U.S. standard population). The Joinpoint Regression Software was used to calculate annual percentage change (APC) and average APC (AAPC). P-value < 0.05 was considered statistically significant.

Results: There were 48 692 deaths attributed to pancreatic cancer in Texas between 2000 – 2020. Pancreatic cancer mortality rates were higher in males than females. However, mortality rates have been significantly increasing in females (AAPC 0.21, P< 0.01) than males (AAPC 0.15, P 0.45). As regards race, mortality rates were higher in Non-Hispanic (NH) Blacks (13.7 per 100,000) compared to NH Whites (10.3 per 100,000) and Hispanic (8.9 per 100,000). Overall, the mortality rates have been decreasing in NH Black males (AAPC -1.06, P= 0.03) and Hispanic males (AAPC -0.67, P = 0.05) and increasing in NH White males (AAPC 0.39, P = 0.02). Similarly, in NH White females, mortality rates have been increasing significantly (AAPC 0.5 P< 0.01) and have been decreasing in NH Black females (AAPC -0.56, P = 0.08) and Hispanic females (AAPC -0.06, P = 0.84) though not statistically significant.

Discussion: The study shows overall higher mortality rates in males and NH Blacks. However, Pancreatic cancer mortality rates are increasing in females and NH Whites. Further studies are needed to investigate the underlying reasons for these disparities in pancreatic cancer.


Disclosures:


Ooreoluwa Fasola, MD. P1746 - Gender and Racial Disparities in Pancreatic Cancer Mortality in Texas: A Statewide Population-Based Study, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.