P1748 - Nationwide Burden and Trend of Gallbladder and Biliary Disease Attributable to High BMI in the Last 3 Decades: Secondary Analysis for the Global Burden of Disease Study 2021

George Mathew Mukalil, MD¹, Akhilesh Sharma, MBBS², Asmita Gera, MBBS³, Abobakr Saleh, MBBS⁴, Amit Banerjee, MBBS⁵, Shadi Abuhashem, MD⁶, Bhargav Koyani, MD⁷, Pragathi Munnangi, MBBS⁸, Rani Ratheesh, MD⁹, Lalitkumar Patel, MBBS¹⁰, Gunjan Kochhar, MBBS¹¹, Hardik Dineshbhai. Desai, MBBS¹², Tanvi Koduru, BS¹³, Himanshu Koyani, MBBS, MS^14
1Central Michigan University, Saginaw, MI; ²Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India; ³Tianjin Medical University, Tianijin, Tianjin, China; ⁴Kasr Alainy Medical School, Cairo University, Cairo, Al Bahr al Ahmar, Egypt; ⁵Stanley Medical College, Chennai, Tamil Nadu, India; ⁶Alquds University, Gaza, Palestinian Territories; ⁷Saint Francis Hospital, Evanston, Evanston, IL; ⁸N.R.I Medical College, Guntur, Andhra Pradesh, India; ⁹Dr. MGR Medical University, Chennai, Tamil Nadu, India; ¹⁰Suburban Medical Center, Schaumburg, IL; ¹¹Punjab Institute of Medical Sciences, Jalandhar, Punjab, India; ¹²Gujarat Adani Institute of Medical Sciences, Ahmedabad, Gujarat, India; ¹³Bergen Community College, Paramus, NJ; ¹⁴Sterling Hospital, Rajkot, Gujarat, India

Introduction: The global obesity epidemic has profound implications for public health, with an estimated 650 million adults classified as obese worldwide as per World Health Organization (WHO) 2021 data. The global rise in obesity rates correlates with increased morbidity from various non-communicable diseases. Despite this growing recognition, comprehensive analyses quantifying the burden of gallbladder and biliary diseases (GBD) attributable to high body-mass index (BMI) across different global regions remain sparse.

Methods: Using Global Burden of Disease 2021 tool, We estimated deaths, years lived with disability (YLDs), years of life lost (YLL) by age, sex, year and location due to GBD attributable to HBMI in 204 Countries and territories from 1990-2021. Results were presented in absolute counts and age-standardized rate (per 100,000 person years).

Results: The total number of deaths increased from 21,102 (95% Uncertainty Interval: 4,725-35,435) in 1990 to 46,715 (10,268-79,843) in 2021. Regionally, Central sub-Saharan Africa saw the largest increase in the total percentage change (TPC) in age-standardized mortality rate (ASMR), with a 69% rise from 1999-2021. East Asia experienced the most significant rise in age-standardized YLDs rate (ASYLDR), with a 76% increase in TPC. Socio-demographically, the highest TPC in ASMR was observed in low Socio-Demographic Index (SDI) countries at 31%, followed by a 38% increase in ASYLDR in middle SDI countries. Nationally, Greece recorded the highest TPC in ASMR at 143%, followed by the United Kingdom at 125%. Age-wise, individuals aged 20-54 years accounted for 4,219 deaths, while those aged 55 and above accounted for 42,396 deaths in 2021. In terms of gender, males exhibited a higher increase in burden with a TPC in deaths of 150% compared to females at 105%, and in YLDs at 153% versus 107%, and YLLs at 117% versus 78% from 1990-2021.

Discussion: Deaths due to GBD attributable to HBMI accounted for 35.63% of all GBD related casualties in 2021. This rising burden underscores the urgent need for public health interventions and policymaker action. Preventative strategies are crucial, as they are more effective than treatment. The adoption of e-health and m-health initiatives is vital to educate the public and promote healthier lifestyle choices, helping to curb the increasing trend in HBMI-related health issues.



Disclosures:


George Mathew Mukalil, MD¹, Akhilesh Sharma, MBBS², Asmita Gera, MBBS³, Abobakr Saleh, MBBS⁴, Amit Banerjee, MBBS⁵, Shadi Abuhashem, MD⁶, Bhargav Koyani, MD⁷, Pragathi Munnangi, MBBS⁸, Rani Ratheesh, MD⁹, Lalitkumar Patel, MBBS¹⁰, Gunjan Kochhar, MBBS¹¹, Hardik Dineshbhai. Desai, MBBS¹², Tanvi Koduru, BS¹³, Himanshu Koyani, MBBS, MS¹⁴. P1748 - Nationwide Burden and Trend of Gallbladder and Biliary Disease Attributable to High BMI in the Last 3 Decades: Secondary Analysis for the Global Burden of Disease Study 2021, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.