P2103 - About Her: Trends in Colorectal Cancer Mortality Among Reproductive-Aged Women in the United States

M Danial Ali Shah, MD¹, Umar Hayat, MD², Anila Mahesh, MD², Hasan Zerti, MD², Aamir Saeed, MD³, Azhar Hussain, MBBS⁴, Amna Iqbal, MD⁵, Waqas Rasheed, MD⁶, Muhammad Kamal, MD⁷, Manesh Kumar Gangwani, MD⁸, Hassam Ali, MD⁹, Dushyant S. Dahiya, MD¹⁰, Faisal Kamal, MD^11
1King Edward Medical University, Lahore, Punjab, Pakistan; ²Geisinger Wyoming Valley Medical Center, Wilkes-Barre, PA; ³Vanderbilt University Medical Center, Nashville, TN; ⁴SUNY Upstate Medical University, Syracuse, NY; ⁵University of Toledo Medical Center, Toledo, OH; ⁶University of Kentucky, Lexington, KY; ⁷Hackensack Meridian Health, Roselle Park, NJ; ⁸University of Toledo, Toledo, OH; ⁹ECU Health Medical Center, Greenville, NC; ¹⁰The University of Kansas School of Medicine, Kansas City, KS; ¹¹Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA

Introduction: Despite advancements in treating colorectal cancer (CRC), a significant gap remains in understanding the mortality rates among reproductive-aged women with CRC in the United States. This study aims to uncover the disparities within this specific group and guide future healthcare policies.

Methods: This study used the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) database to analyze CRC-related deaths among women aged 15-44 from 1999 to 2020. We examined demographic differences in mortality rates over time, considering age, ethnicity, and geographic areas. Results are reported as age-adjusted mortality rates (AAMR) with 95% confidence intervals (CI), computed by standardizing CRC-related deaths in the US in 2000. Joinpoint regression analysis calculated the average annual percentage change (AAPC).

Results: Between 1999 and 2020, a total of 14,757 women aged 15-44 died from CRC in the US, with an AAMR of 1.1 per 100,000 (95% CI: 1.1-1.2). The AAMR showed an upward trend from 1.1 in 1999 to 1.3 in 2020 (AAPC 0.87; 95% CI: 0.40-1.41). However, this overall rise in mortality rates masked disparities: Non-Hispanic Black women had the highest AAMR at 1.7, while Hispanics displayed the lowest mortality rates at 0.9. Geographically, the South emerged as the most affected region with an AAMR of 1.3, contributing to 42.4% of deaths, where rural areas demonstrated higher AAMR compared to urban areas (1.4 vs. 1.1). State variation was most pronounced in Mississippi and Arkansas (1.7 and 1.6) and lowest in Wisconsin (0.8). The mortality rate was higher among the older age group (35-44), accounting for 79.3%.

Discussion: CRC-related mortality among reproductive-aged women has increased from 1999 to 2020, highlighting persistent disparities. Our analysis underscores the unequal burden of CRC-related deaths on non-Hispanic Black women and individuals in the Southern United States, underscoring the need for targeted public health interventions.



Disclosures:


M Danial Ali Shah, MD¹, Umar Hayat, MD², Anila Mahesh, MD², Hasan Zerti, MD², Aamir Saeed, MD³, Azhar Hussain, MBBS⁴, Amna Iqbal, MD⁵, Waqas Rasheed, MD⁶, Muhammad Kamal, MD⁷, Manesh Kumar Gangwani, MD⁸, Hassam Ali, MD⁹, Dushyant S. Dahiya, MD¹⁰, Faisal Kamal, MD¹¹. P2103 - About Her: Trends in Colorectal Cancer Mortality Among Reproductive-Aged Women in the United States, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.