P2115 - Clinical Outcomes for Female Patients With Early Onset Colorectal Cancer: An Analysis of the National Inpatient Sample

Tony Elias, MS¹, Danielle C. Thor, DO, MA², Mujtaba Chohan, DO², Kyrillos Girgis, MD³, Rafail Beshai, DO⁴, Lucy Joo, DO^5
1Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ; ²Jefferson Health, Stratford, NJ; ³Newark Beth Israel Medical Center, Newark, NJ; ⁴Virtua Health System, Washington Township, NJ; ⁵Jefferson Health, Cherry Hill, NJ

Introduction: Despite recent global decreases in overall cancer incidence, early-onset colorectal cancer (EOCRC) is steadily increasing in incidence in western populations. Limited data is available on the sex-based correlations for this unfortunately expanding population. We sought to examine the national inpatient sample database to describe in-hospital outcomes among the female population with EOCRC.

Methods: Data were extracted from the National Inpatient Sample (NIS) Database for 2019 and 2020. The NIS was searched for hospitalizations of adult patients with EOCRC, defined as colorectal cancer in patients 50 years old or younger. We then examined the outcomes of patients who were females. Multivariate logistic was used to adjust for confounders. The primary outcome was inpatient mortality. SPSS software was used for statistical analysis.

Results: This study included 11,820 patients with EOCRC, of which 5,433 (46%) were female. Females had a higher prevalence of obesity (10.0% versus 9.4%, p< 0.001). Furthermore, females had a lower prevalence of smoking (13.8% versus 16.3%, p< 0.001). Multivariate regression showed that female patients with EOCRC had higher inpatient mortality (OR 1.758, CI 1.620-1.966, p< 0.001). On secondary analysis, it has shown that female patients with EOCRC had higher odds of having non-alcoholic fatty liver disease (OR 1.840, CI 1.612-2.101, p< 0.001), anemia (OR 1.942, CI 1.890-1.995, p< 0.001), thrombocytopenia (OR 1.928, Cl 1.798-2.068, p< 0.001), sepsis (OR 1.932, CI 1.852-2.015), esophagitis (OR 1.890, Cl 1.813-1.972, p< 0.001), esophageal ulcer (OR 1.577, Cl 1.250-1.990, p< 0.001), and severe liver disease (OR 1.862, Cl 1.809-1.916, p< 0.001).

Discussion: In this nationally representative, population‐based retrospective cohort study, female patients with EOCRC were associated with higher mortality and worse outcomes.


Disclosures:


Tony Elias, MS¹, Danielle C. Thor, DO, MA², Mujtaba Chohan, DO², Kyrillos Girgis, MD³, Rafail Beshai, DO⁴, Lucy Joo, DO⁵. P2115 - Clinical Outcomes for Female Patients With Early Onset Colorectal Cancer: An Analysis of the National Inpatient Sample, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.