P2198 - Gastroesophageal Reflux Disease (GERD) and Risk of Incident Acute Myocardial Infarction: A Systematic Review and Meta-analysis of Cohort Studies
Tinsae Anebo, MD1, Phuuwadith Wattanachayakul, MD1, Karecia Byfield, MBBS1, Carlo Gabriel C. Casipit, MD1, Edward J. Marines, DO2, Evan Isaacs, DO3, Thitiphan Srikulmontri, MD1, Fnu Deepali, MD4, Hamza Tahir, MBBS, MD2, Elvis Obomanu, MBBS5, Festus O. Ibe, MD5, Colton F. Jones, MBBS1, Kevin Robinson, MD1, Jordan Carty, MD1, Oluwanifemi Balogun, MD1, Abiodun Idowu, MD2, Thanathip Suenghataiphorn, MD6, Tesfaye Yadete, MD7, Abdulrahim Yusuf Mehadi, MD8, Michael L. Davis, DO1 1Albert Einstein Medical Center, Philadelphia, PA; 2Jefferson Einstein Hospital, Philadelphia, PA; 3Einstein Healthcare Network, Philadelphia, PA; 4Einstein Medical Center, Philadelphia, PA; 5Jefferson-Einstein Hospital, Philadelphia, PA; 6Griffin Hospital, Derby, CT; 7Cleveland Clinic, Cleveland, OH; 8John H. Stroger Hospital of Cook County, Chicago, IL
Introduction: Recent data found that gastroesophageal reflux disease (GERD) is linked to worse clinical outcomes in patients with pre-existing cardiovascular disease, including an increased risk of coronary artery calcification progression and rehospitalization. However, there is still conflicting evidence on whether GERD is a risk factor for developing acute myocardial infarction (AMI). Therefore, we aim to explore this association using all available data on GERD and the risk of incident AMI.
Methods: We conducted a systematic review to examine the association between GERD and the incidence of AMI. We searched MEDLINE and EMBASE databases from inception to May 2024. Studies were included if they reported on cohorts with and without GERD and tracked the incidence of AMI. We extracted relative risk (RR), hazard ratio (HR), and 95% confidence intervals (CIs) from each study, combining the data using the generic inverse variance method.
Results: Our meta-analysis included six cohort studies with 1,324,362 participants who met the eligibility criteria. We found that patients with GERD had a 1.27-fold higher risk of incident AMI compared to those without GERD. The pooled relative risk (RR) was 1.27 (95% CI: 1.13-1.43; I² = 88%, p < 0.001). The funnel plot showed no evidence of publication bias.
Discussion: Our study revealed that GERD is associated with a higher incidence of AMI. Further research is needed to understand the underlying mechanisms, evaluate preventive strategies, and develop targeted interventions to mitigate this risk and improve patient care.
Figure: Figure 1-GERD increase 1.27-fold risk of acute myocardial infarction Pooled RR = 1.27 (95%CI 1.13-1.43, I2= 88%, P <0.001) Figure 2-Funnel Plot showing no evidence of publication bias
Disclosures:
Tinsae Anebo indicated no relevant financial relationships.
Phuuwadith Wattanachayakul indicated no relevant financial relationships.
Karecia Byfield indicated no relevant financial relationships.
Carlo Gabriel Casipit indicated no relevant financial relationships.
Edward Marines indicated no relevant financial relationships.
Evan Isaacs indicated no relevant financial relationships.
Thitiphan Srikulmontri indicated no relevant financial relationships.
Fnu Deepali indicated no relevant financial relationships.
Hamza Tahir indicated no relevant financial relationships.
Elvis Obomanu indicated no relevant financial relationships.
Festus Ibe indicated no relevant financial relationships.
Colton Jones indicated no relevant financial relationships.
Kevin Robinson indicated no relevant financial relationships.
Jordan Carty indicated no relevant financial relationships.
Oluwanifemi Balogun indicated no relevant financial relationships.
Abiodun Idowu indicated no relevant financial relationships.
Thanathip Suenghataiphorn indicated no relevant financial relationships.
Tesfaye Yadete indicated no relevant financial relationships.
Abdulrahim Yusuf Mehadi indicated no relevant financial relationships.
Michael Davis indicated no relevant financial relationships.
Tinsae Anebo, MD1, Phuuwadith Wattanachayakul, MD1, Karecia Byfield, MBBS1, Carlo Gabriel C. Casipit, MD1, Edward J. Marines, DO2, Evan Isaacs, DO3, Thitiphan Srikulmontri, MD1, Fnu Deepali, MD4, Hamza Tahir, MBBS, MD2, Elvis Obomanu, MBBS5, Festus O. Ibe, MD5, Colton F. Jones, MBBS1, Kevin Robinson, MD1, Jordan Carty, MD1, Oluwanifemi Balogun, MD1, Abiodun Idowu, MD2, Thanathip Suenghataiphorn, MD6, Tesfaye Yadete, MD7, Abdulrahim Yusuf Mehadi, MD8, Michael L. Davis, DO1. P2198 - Gastroesophageal Reflux Disease (GERD) and Risk of Incident Acute Myocardial Infarction: A Systematic Review and Meta-analysis of Cohort Studies, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.
