P2202 - Temporal Trends in the Mortality of Esophageal Malignancies in Canada Over the Past 3 Decades

Ahmed A. Abdulelah, MD¹, Zaid A. Abdulelah, MD², Mohammad Alqaisieh, MD³, Lina AlQirem, MD⁴, Yazan Gharaibeh, MD⁵, Dua' Al-Husni, MD⁶, Amer Khatib, MD^7
1University of Edinburgh, Edinburgh, Scotland, United Kingdom; ²Royal Papworth Hospital, Cambridge, England, United Kingdom; ³Hamilton Medical Center, Dalton, GA; ⁴University of Arkansas for Medical Sciences, Little Rock, AR; ⁵Royal Free London NHS Trust, London, England, United Kingdom; ⁶Cleveland Clinic Foundation, Cleveland, OH; ⁷University of Jordan, Amman, 'Amman, Jordan

Introduction: Esophageal cancer results in significant global health and socioeconomic burden due to the associated morbidity and mortality despite not being among the most prevalent malignancies. Therefore, the evaluation of the temporal trends of esophageal cancer-related mortality in Canada over the past 3 decades is of paramount interest for the effective introduction of advanced therapeutic interventions, preventative measures, and health policies.

Methods: Temporal trends in the mortality of esophageal malignancies in Canada over the past 30 years were initially evaluated by accessing relevant data from the Global Burden of Diseases 2019 database. The Annual Percentage Change (APC) and the Average Annual Percentage Change (AAPC) were stratified by age and gender and calculated using Joinpoint Analysis software (v 5.2.0, National Cancer Institute).

Results: Over the period 1990-2019, a total of 56,030 esophageal cancer-related deaths were reported in Canada with a staggering male predominance of 73.5%. Age stratification revealed a statistically significant increase in esophageal cancer-related mortality across all age groups, with individuals aged 15-49 years old experiencing the highest increment (AAPC 1.96; 95%CI 1.70 to 2.25; p< 0.001). A similar increase in esophageal cancer-related deaths was observed in the 50-74 years old age group with an AAPC of 1.92 (95%CI 1.80 to 2.01; p< 0.001). The least incline was noted in elderly individuals aged 75 years and older with an AAPC of 1.31 (95%CI 1.13 to 1.49; p< 0.001). Stratification by gender also demonstrated a statistically significant incline in esophageal cancer-related mortality in both males and females, with males having a more prominent increase (AAPC 2.03; 95%CI 1.91 to 2.14; p< 0.001 in males and AAPC 0.51; 95%CI 0.35 to 0.64; p< 0.001 in females).

Discussion: Over a span of 3 decades, esophageal cancer-related mortality in Canada witnessed a significant incline across all age groups and in both males and females. Such trends are exceptionally worrisome and mandate prompt interventions to effectively tackle the resultant burden.


Disclosures:


Ahmed A. Abdulelah, MD¹, Zaid A. Abdulelah, MD², Mohammad Alqaisieh, MD³, Lina AlQirem, MD⁴, Yazan Gharaibeh, MD⁵, Dua' Al-Husni, MD⁶, Amer Khatib, MD⁷. P2202 - Temporal Trends in the Mortality of Esophageal Malignancies in Canada Over the Past 3 Decades, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.