P2346 - Nutritional Status and Eating Patterns in Patients With Cyclic Vomiting Syndrome

Subanandhini Subramaniam, MD¹, Saranya Arumugam, MBBS¹, Mahima Vijaybhai Vyas, MBBS¹, Kristen Roberts, PhD, RD², Kebire Gofar, MD, MPH¹, Kristin Goheen, ¹, Praveen Goday, MD³, Thangam Venkatesan, MD^1
1The Ohio State University, Columbus, OH; ²The Ohio State University Wexner Medical Center, Columbus, OH; ³Nationwide Children's Hospital, Columbus, OH

Introduction: Cyclic Vomiting Syndrome (CVS) is a disorder of gut-brain interaction (DGBI), characterized by recurrent episodes of nausea, vomiting, and abdominal pain. Episodes last several days to a week and frequency varies from 3 episodes/year to 2/month where patients are unable to eat or drink placing them at risk of malnutrition and possible restrictive eating. Despite this, there are no data on the nutrition status or the prevalence of disordered eating in CVS. We aimed to determine the presence of malnutrition risk, food insecurity and disordered eating among patients with CVS.

Methods: We performed a cross-sectional study of patients diagnosed with CVS based on Rome IV criteria at a tertiary referral center. Validated questionnaires including 1) The Malnutrition Screening Tool (MST) 2) the Food Security Questionnaire (FSQ) 3) Nine-Item Avoidant/Restrictive Food Intake Disorder (NIAS) and 4) Cannabis Use Identification disorder (CUDIT) were administered. Patients were considered positive for ARFID based on the NIAS subscales (≥10 NIAS-picky eating, ≥9 NIAS-appetite, and ≥10 NIAS-fear). Demographic and clinical data were also obtained. Statistical plan: Interim analysis of 32 patients who completed the study was performed. Descriptive statistics are presented.

Results: Demographics and clinical characteristics of patients are shown in Table 1. Of 32 patients, mean age was 39 ± 16, 23 (72%) were female. Most had long-standing disease with duration of CVS symptoms of 11 ± 10 years and 24 (74%) had moderate-severe CVS. Ten (33%) were at risk for malnutrition and 4 (12.5%) had evidence of food insecurity. Thirteen patients (40.6%) screened positive for ARFID. The subscale scores for ARFID showed that 4 (12.5%) were picky eaters, 9 (28.1%) had poor appetite, and 10 (31.3%) had fear of eating. Of those who screened positive for ARFID, 6 (46%) used cannabis primarily for relief of nausea.

Discussion: These preliminary findings of patients with CVS supports a high risk for malnutrition and ARFID. These could be related to long-standing disease and fear of eating leading to avoidant/restrictive eating behaviors. These findings support early referral of patients with moderate-severe CVS to a registered dietitian for screening and nutritional therapy which can potentially improve overall patient outcomes. These findings need to be confirmed with larger studies and warrant investigation.


Disclosures:


Subanandhini Subramaniam, MD¹, Saranya Arumugam, MBBS¹, Mahima Vijaybhai Vyas, MBBS¹, Kristen Roberts, PhD, RD², Kebire Gofar, MD, MPH¹, Kristin Goheen, ¹, Praveen Goday, MD³, Thangam Venkatesan, MD¹. P2346 - Nutritional Status and Eating Patterns in Patients With Cyclic Vomiting Syndrome, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.