P2663 - Trends in Outcomes Among Hospitalized Patients With ST Elevation Myocardial Infarction and Ulcerative Colitis Over a Decade: A United States Population Based Study
Oluwanifemi Balogun, MD1, Jordan Carty, MD1, Tinsae Anebo, MD1, Blanche Echikunwoke, MD1, Hamza Tahir, MBBS, MD2, Elizabeth Soladoye, MD, MPH3, Lisa Barrett, DO1, Stephanie Tzarnas, MD4, Emmanuel Akuna, MD1, James Walter, MD5 1Albert Einstein Medical Center, Philadelphia, PA; 2Jefferson Einstein Hospital, Philadelphia, PA; 3Piedmont Athens Regional, Athens, GA; 4Einstein Medical Center, Philadelphia, PA; 5Einstein Healthcare Network, Philadelphia, PA
Introduction: Chronic inflammation is linked to increased cardiovascular risk. Ulcerative colitis (UC) is characterized by chronic inflammation of the gastrointestinal tract. Mortality from ST elevation myocardial infarction (STEMI) is decreasing nationwide, yet little data examining trends in STEMI mortality among UC patients is available
Methods: This is a retrospective study of adult patients hospitalized with STEMI in hospitals across the United States from 2010 to 2020. We utilized the National Inpatient Sample (NIS) database using the international classification of disease tenth edition (ICD-10) codes to identify patients. We included all principal admissions for STEMI within this time frame and excluded admissions with age less than 18 years. Confounders were adjusted for using multivariable regression analyses. All analyses were conducted at a significance level of 5% (p < 0.05) with a 95% confidence interval (CI)
Results: A total of 6,664,758 patients with STEMI were included from 2010 to 2020. Of this population, 13,472 patients had ulcerative colitis. Among patients with STEMI and ulcerative colitis, the in-hospital mortality rate was 4.1% in 2010, reached a peak of 7.6% in 2013, and was lowest in 2019 at 1.9%. While in patients with STEMI and no UC, the mortality rate was 6.8% in 2010 and decreased to 5.6% in 2020 (aOR 0.97 p=< 0.0001 CI 0.967-0.973).Furthermore, we saw an increase in the use of percutaneous coronary angiography from 2010 to 2020 in both groups (aOR 1.06 p=< 0.0001 CI 1.06 -1.07). The use of Coronary Artery Bypass Graft (CABG) was relatively steady (aOR 0.99 p=0.002 CI 0.98-0.99)
Discussion: Mortality in patients with ulcerative colitis and STEMI overall decreased over the course of a decade. This is likely due to improvement in treatment modalities such as the use of biologics and increased utilization of coronary artery stenting. The COVID-19 pandemic likely explains the rise in mortality in 2020.
Figure: Yes
Disclosures:
Oluwanifemi Balogun indicated no relevant financial relationships.
Jordan Carty indicated no relevant financial relationships.
Tinsae Anebo indicated no relevant financial relationships.
Blanche Echikunwoke indicated no relevant financial relationships.
Hamza Tahir indicated no relevant financial relationships.
Elizabeth Soladoye indicated no relevant financial relationships.
Lisa Barrett indicated no relevant financial relationships.
Stephanie Tzarnas indicated no relevant financial relationships.
Emmanuel Akuna indicated no relevant financial relationships.
James Walter: Eli Lilly – Advisor or Review Panel Member. Medtronic – Consultant.
Oluwanifemi Balogun, MD1, Jordan Carty, MD1, Tinsae Anebo, MD1, Blanche Echikunwoke, MD1, Hamza Tahir, MBBS, MD2, Elizabeth Soladoye, MD, MPH3, Lisa Barrett, DO1, Stephanie Tzarnas, MD4, Emmanuel Akuna, MD1, James Walter, MD5. P2663 - Trends in Outcomes Among Hospitalized Patients With ST Elevation Myocardial Infarction and Ulcerative Colitis Over a Decade: A United States Population Based Study, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.
