P2684 - Relationship Between Gastroparesis and Inflammatory Bowel Disease: A United States Nationwide Sized Database Analysis

Alejandro J. Nieto Dominguez, MD, Sarah Eichinger, DO, Daniel Guifarro, MD
John H. Stroger, Jr. Hospital of Cook County, Chicago, IL

Introduction: Inflammatory bowel disease (IBD) is a disorder characterized by inflammation of GI tract and is associated with many other diseases. Ulcerative colitis (UC) and Crohn’s disease (CD) are the two main subtypes of IBD, and each has a unique set of symptoms and complications that affect a patient’s quality of life including abdominal pain, chronic diarrhea, malabsorption, weight loss, hematochezia, and melena. Gastroparesis is a condition in which there is delayed emptying of the stomach in the absence of gastric obstruction which has multiple proposed etiologies and can be comorbid with other gastrointestinal disorders. There is scant data demonstrating a possible relationship between IBD and gastroparesis, with a few case reports that describe presence of gastroparesis in patients with IBD. Our aim is to further study this association.

Methods: Our study utilized data from the National Inpatient Sample, a comprehensive US database of inpatient hospital stays, from 2016 to 2019. We specifically focused on patients admitted with gastroparesis and evaluated the relationship with IBD. For our statistical analysis, we used STATA version 18.

Results: This study was adjusted for confounders including (age, race, smoking history, CKD, dyslipidemia, coronary artery disease and various hospital characteristics. We found that the presence of gastroparesis was significantly associated with the presence of CD (OR: 2.73, CI: 2.33 to 3.22, P < 0.01). Similarly, in the analysis of UC, there was a significant association with gastroparesis (OR: 2.06, CI: 1.57 to 2.70, P < 0.01).

There were 147 total patients with gastroparesis and CD, compared to 55 with gastroparesis and UC. The mean age of patients with gastroparesis and CD was significantly lower at 41.37 years compared to 48.59 years for those without CD. Similarly, for UC, the mean age was lower at 46.98 years for patients with gastroparesis and UC, compared to 48.49 years for those without UC.

Discussion: Our study found a significant association between IBD and gastroparesis. Previous studies have shown that patients with active IBD can have delayed gastric emptying which can improve after appropriate treatment. Further studies evaluating strategies for prevention or management of gastroparesis in this special population should be performed, as well as epidemiological studies focusing on the prevalence of disease.


Disclosures:


Alejandro J. Nieto Dominguez, MD, Sarah Eichinger, DO, Daniel Guifarro, MD. P2684 - Relationship Between Gastroparesis and Inflammatory Bowel Disease: A United States Nationwide Sized Database Analysis, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.