P2760 - Race as a Risk Factor for Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis

Hayley K. Rogers, MD¹, James Haddad, MD¹, Po-Hong Liu, MD¹, Patrick Chang, MD², Jennifer Phan, MD², Thomas Tielleman, MD^1
1University of Texas Southwestern, Dallas, TX; ²University of Southern California, Los Angeles, CA

Introduction: Pancreatitis is a well-known complication of endoscopic retrograde cholangiopancreatography (ERCP). Identifying additional risk factors for post-ERCP pancreatitis (PEP) will assist endoscopists in stratifying patients and optimizing prophylaxis strategies. As there is limited data on how race and ethnicity impact a patient’s risk for PEP, we analyzed this relationship in a diverse cohort of patients.

Methods: This retrospective multicenter study was conducted at two hospitals with notably different patient demographics, a county and a univertsity hospital. ERCP reports from July 1st 2022 to February 28th 2023 were analyzed. We used univariable and multivariate logistic regression models to determine independent predictors of PEP. A two-tailed p< 0.05 was considered statistically significant.

Results: A total of 755 patients were included, and the overall rate of PEP was 5.03%. In the overall cohort, 48.1% of the population was Hispanic, and 51.9% of patients had a native papilla.
Non-Hispanic patients had a significantly higher rate of PEP (OR: 4.40, 95% CI 1.97-9.82, p< 0.001). This remained true when including only ERCPs performed for biliary interventions and excluding cases with intentional pancreatic duct work. When analyzing only native papilla ERCPs, the only factor related to a significantly higher rate of PEP was non-Hispanic race (OR 4.36, CI 1.83-10.4, p< 0.001).

Discussion: We utilized a diverse patient cohort and showed that Hispanic patients were less likely to develop PEP. These results may inform future research on the underlying biological mechanisms of this association and help identify patients at higher risk of PEP.


Disclosures:


Hayley K. Rogers, MD¹, James Haddad, MD¹, Po-Hong Liu, MD¹, Patrick Chang, MD², Jennifer Phan, MD², Thomas Tielleman, MD¹. P2760 - Race as a Risk Factor for Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.