P2883 - Sarcopenia and Cirrhosis: Outcomes and Trends Over Five Years -- A Nationwide Retrospective Analysis

Anuj R. Sharma, MBBS¹, Manasa Ginjupalli, MBBS, MD², Chaula Desai, MD¹, Vikash Kumar, MD³, Vidhi Maini, ⁴, Sweta Lohani, MBBS, MD¹, Suriya Baskar, MD¹, Saigopal R. Gujjula, MD¹, Iyad Al-bustami, MD, MPH(c)⁵, Rasha H. Saleh, MD¹, Matthew Peachey, MD¹, Jeeva Jaganathan, MD¹, Raissa Nana Sede Mbakop, MD⁶, Camelia Ciobanu, MD¹, Amr Dokmak, MD¹, Praneeth Bandaru, MBBS, MD¹, Vijay Reddy Gayam, MD⁷, Arnold N. Forlemu, MD, MPH⁸, Denzil Etienne, MD¹, Madhavi Reddy, MD, FACG^1
1Brooklyn Hospital Center, Brooklyn, NY; ²The Brooklyn Hospital Center, New York, NY; ³Creighton University School of Medicine, Brooklyn, NY; ⁴Brooklyn Hospital Center, Brroklyn, NY; ⁵Brooklyn Hospital Center, Houston, TX; ⁶The Brooklyn Hospital Center, Brooklyn, NY; ⁷University of Texas Southwestern Medical Center, Dallas, TX; ⁸Brooklyn Hospital Center, Athens, GA

Introduction: Liver cirrhosis is a chronic liver disease characterized by the replacement of healthy liver tissue with scar tissue, leading to impaired liver function1. Sarcopenia, defined as the loss of skeletal muscle mass and strength, is a common complication in patients with cirrhosis and is proposed to be an independent predictor of outcomes in cirrhosis2. We aimed to investigate the outcomes associated with sarcopenia in cirrhotic patients over the years using the National Inpatient Sample (NIS) Database.

Methods: A retrospective analysis was performed using the NIS Database for the years 2016-2020. Inpatient admissions with a diagnosis of cirrhosis were identified each year using ICD-10 codes in STATA-17. The association between sarcopenia and primary and secondary outcomes was studied. Categorical variables were compared using the chi-square test, while continuous variables were compared using the t-test. Multivariable regression analyses were performed, adjusting for demographics, hospital level characteristics and relevant comorbidities including obesity, smoking status, opioid use, dyslipidemia, hypertension, diabetes, chronic kidney disease, congestive heart failure, coronary artery disease, peripheral vascular disease, testosterone deficiency, and malnutrition.

Results: A total of 3,738,364 inpatient admissions for adults with cirrhosis were identified, of which 4,885 had sarcopenia (Mean age 58.24yrs; 37.67% Females, 62.3% Males). Multivariate regression analysis of patients with cirrhosis showed sarcopenic patients had higher odds of spontaneous bacterial peritonitis (Odds Ratio (OR) 1.66, 95% CI 1.31-2.10), portal vein thrombosis (OR 1.94, 95% CI 1.54-2.44), hepatocellular carcinoma (OR 1.38, 95% CI 1.06-1.78), ascites (OR 1.8, 95% CI 1.54-2.10), transjugular intrahepatic portosystemic shunt (TIPS) placement (OR 3.87, 95% CI 2.56-5.84), and liver failure (OR 2.39, 95% CI 2.01-2.84) compared to non-sarcopenic patients. There was non-significant association with encephalopathy (OR 0.79, 95% CI 0.55-1.15) and variceal bleeding (OR 1.08, 95% CI 0.83-1.40). Trends of each outcome studied in each year are shown in Figure 1.

Discussion: Our analysis revealed sarcopenia is associated with higher odds of certain complications in hospitalized cirrhotic patients, which might lead to worse outcomes, longer hospital stays and healthcare expenditure. Further prospective studies are needed to confirm these associations and explore potential interventions targeting sarcopenia in cirrhotic patients.



Disclosures:


Anuj R. Sharma, MBBS¹, Manasa Ginjupalli, MBBS, MD², Chaula Desai, MD¹, Vikash Kumar, MD³, Vidhi Maini, ⁴, Sweta Lohani, MBBS, MD¹, Suriya Baskar, MD¹, Saigopal R. Gujjula, MD¹, Iyad Al-bustami, MD, MPH(c)⁵, Rasha H. Saleh, MD¹, Matthew Peachey, MD¹, Jeeva Jaganathan, MD¹, Raissa Nana Sede Mbakop, MD⁶, Camelia Ciobanu, MD¹, Amr Dokmak, MD¹, Praneeth Bandaru, MBBS, MD¹, Vijay Reddy Gayam, MD⁷, Arnold N. Forlemu, MD, MPH⁸, Denzil Etienne, MD¹, Madhavi Reddy, MD, FACG¹. P2883 - Sarcopenia and Cirrhosis: Outcomes and Trends Over Five Years -- A Nationwide Retrospective Analysis, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.