P4274 - Renal and Urinary Complications in Patients With Inflammatory Bowel Disease: Insights From the National Inpatient Sample 2016-2020

Bisher Sawaf, MD¹, Shahem Abbarah, MD², Mhd Kutaiba Albuni, MD³, Amine Rakab, MD, MSc^4
1University of Toledo Health Sciences Campus, Toledo, OH; ²MedStar Health, Baltimore, MD; ³TriHealth, Doha, Ad Dawhah, Qatar; ⁴Weill Cornell Medicine, Doha, Ad Dawhah, Qatar

Introduction: Inflammatory bowel disease (IBD) is known to predispose patients to extraintestinal manifestations, including complications affecting the kidney and urinary system. This study aims to investigate the prevalence of acute kidney injury (AKI), kidney stones, and chronic kidney disease (CKD) stages among hospitalized patients with IBD compared to those without IBD.

Methods: Data from the National Inpatient Sample (2016-2020) were analyzed using ICD-10 codes to identify variables related to acute kidney injury (AKI), kidney stones, and chronic kidney disease (CKD) stages. Statistical analysis was performed using STATA version 15. We assessed the incidence of these complications in both patients with inflammatory bowel disease (IBD) and those without IBD. Additionally, regression analysis was conducted to investigate potential confounders.

Results: Our analysis included a total of 32,966,720 admissions, of which 315,167 were for patients with IBD and 32,651,553 were for patients without IBD. Among hospitalized patients, those with IBD had significantly higher rates of AKI compared to non-IBD patients: 16.16% (50,931) versus 13.69% (4,470,878), respectively (p < 0.0001). Similarly, the prevalence of kidney stones was notably elevated among IBD patients at 1.72% (5,416), whereas it was 0.77% (249,998) in non-IBD patients (p < 0.0001). Regarding CKD stages among IBD patients, 5.97% (18,802) had stage 3 CKD, 1.56% (4,914) had stage 4 CKD, 1.97% (6,194) had end-stage renal disease (ESRD), and 2.87% (9,046) had unspecified CKD. After adjustment, IBD showed a significant statistical association with AKI (OR:1.36;95%CI:1.34-1.37; P < 0.0001), and urolithiasis (OR:2.20;95%CI:2.14-2.26; P< 0.0001), however, IBD did not show significant relation with CKD (OR:1.01;95%CI: 0.99-1.02; P=0.359).

Discussion: This study underscores a heightened risk of renal complications, including AKI, kidney stones, and various stages of CKD, among hospitalized patients with IBD compared to those without IBD. These findings emphasize the critical need for rigorous monitoring and targeted management strategies to preserve renal health in patients with IBD.


Disclosures:


Bisher Sawaf, MD¹, Shahem Abbarah, MD², Mhd Kutaiba Albuni, MD³, Amine Rakab, MD, MSc⁴. P4274 - Renal and Urinary Complications in Patients With Inflammatory Bowel Disease: Insights From the National Inpatient Sample 2016-2020, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.