P4604 - Increasing Incidence and Mortality of Alcoholic Liver Disease in Patients Under the Age of 50 Years: Insights From the National Inpatient Sample (NIS)

Mohamed Ahmed, MD, MSc¹, Noor Hassan, MD², Islam Mohamed, MD³, Fouad Jaber, MD¹, Saqr Alsakarneh, MD¹, Hassan Ghoz, MD^1
1University of Missouri - Kansas City School of Medicine, Kansas City, MO; ²University of Missouri Kansas City School of Medicine, Kansas City, MO; ³University of Missouri, Kansas City, MO

Introduction: Alcohol associated liver disease is increasing in the United States especially in the younger population. This is likely secondary to rising alcohol consumption and alcohol use disorder in the young population. The aim of this study is to examine the trend of admissions and mortality secondary to alcoholic liver disease.

Methods: Patients hospitalized between 2016 and 2020 who were admitted for Alcoholic liver disease (ALD) were identified using International Classification of Diseases Code,10^th Revision Clinical Modification (ICD-10) identified from the Healthcare Cost and Utilization Project databases (HCUP) using the National inpatient sample (NIS). Patients under the age of 50 were identified and trends, mortality rates and other characteristics were examined.

Results: A total of 781744 hospitalizations were identified between 2016 and 2020 for alcoholic liver disease, 326245 (41.7% of patients) were under the age of 50. The proportion of patients under the age of 50 years admitted with ALD increased from 40.1% in 2016 to 44.2% in 2020 of all admissions with ALD.

This increase was statistically significant ( p< 0.001). The mortality rate among patient’s underage of 50 years increased from 2.47% in 2016 to 3.56% in 2020 after adjusting for sex, race and other comorbidities like heart failure, COPD and diabetes mellitus. The increase in hospitalizations seemed to be consistent among all race groups. The mean length of stay for patient under 50 years has increased from 5 days in 2016 to 6.1 days in 2020 with this increase being statistically significant ( p < 0.05). There has also been an increase in the total charges associated with these admissions. The increase was equal in both males and females.

Discussion: This study shows an increase in the number of hospital admissions related to alcohol liver disease in patients less than 50 years. Further studies are needed to examine the causes of such an increase and possible preventive interventions to help control this increase.


Disclosures:


Mohamed Ahmed, MD, MSc¹, Noor Hassan, MD², Islam Mohamed, MD³, Fouad Jaber, MD¹, Saqr Alsakarneh, MD¹, Hassan Ghoz, MD¹. P4604 - Increasing Incidence and Mortality of Alcoholic Liver Disease in Patients Under the Age of 50 Years: Insights From the National Inpatient Sample (NIS), ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.