St. George's University School of Medicine Brooklyn, NY
Eeman Ahmad, MBBS1, Shahzaib Ahmed, MBBS1, Shamsa M. Qaadri, BSc2, Iyad Al-bustami, MD, MPH(c)3, Abbas H.. Mallick, MD4, Umar Akram, 5, Ehsan Majeed, MBBS1 1Fatima Memorial Hospital College of Medicine and Dentistry, Lahore, Punjab, Pakistan; 2St. George's University School of Medicine, Brooklyn, NY; 3Brooklyn Hospital Center, Houston, TX; 4Brooklyn Hospital Center, Brooklyn, NY; 5Allama Iqbal Medical College, Lahore, Punjab, Pakistan
Introduction: Peritonitis fatality depends on various factors, including status of the patient, the reason behind the inflammation, and the interventions undertaken. Our aim is to describe peritonitis-related mortality trends in the United States (US).
Methods: Age-adjusted mortality rates (AAMR) for peritonitis in the US were extracted from the CDC WONDER database from 1999-2020. AAMRs were stratified according to sex, race, and region, and changes in AAMRs were estimated by calculating Annual Percent Change (APC) using the Joinpoint Regression Program (V 5.2.0).
Results: A significant decrease in the AAMR was seen from 1999 to 2009 (APC: -2.87, 95% CI: -3.60 to -2.32), after which an increase was observed until 2020 (APC: 0.59, 95% CI: 0.14 to 1.20). Males had a higher AAMR (2.38, 95% CI: 2.36 - 2.40) than females (1.88, 95% CI: 1.86 - 1.89) throughout the study period. Racial disparities in mortality trends were noted, as non-Hispanic (NH) American Indian or Alaska Natives exhibited the highest AAMR (3.57, 95% CI: 3.39 - 3.74), followed by NH Black or African Americans (2.55, 95% CI: 2.51 - 2.59), Hispanic or Latinos (2.12, 95% CI: 2.08 - 2.15), NH Whites (2.05, 95% CI: 2.04 - 2.07), and NH Asian or Pacific Islanders (1.35, 95% CI: 1.31 - 1.40).
Regional trends were noted as well. The highest AAMRs were noted in New Mexico (2.91, 95% CI: 2.75 - 3.06), Alaska (2.72, 95% CI: 2.41 - 3.03), the District of Columbia (2.67, 95% CI: 2.39 - 2.95), and Washington (2.65, 95% CI: 2.56 - 2.73). The AAMR in Urban areas (2.09, 95% CI: 2.07 - 2.10) was higher than that in Rural areas (2.28, 95% CI: 2.25 - 2.30), and the gap between them widened from 1999 to 2020. In terms of census regions, the West exhibited the highest AAMR (2.37, 95% CI: 2.35 - 2.40), followed by the Midwest (2.22, 95% CI: 2.20 - 2.25), the South (1.99, 95% CI: 1.98 - 2.01) and the Northeast (1.95, 95% CI: 1.93 - 1.98).
Discussion: Focused policies that target vulnerable populations are essential in order to curb the increase in mortality. Behavioural, social, and cultural factors must be considered to address racial and regional disparities across the US.
Note: The table for this abstract can be viewed in the ePoster Gallery section of the ACG 2024 ePoster Site or in The American Journal of Gastroenterology's abstract supplement issue, both of which will be available starting October 27, 2024.
Disclosures:
Eeman Ahmad indicated no relevant financial relationships.
Shahzaib Ahmed indicated no relevant financial relationships.
Shamsa Qaadri indicated no relevant financial relationships.
Iyad Al-bustami indicated no relevant financial relationships.
Abbas Mallick indicated no relevant financial relationships.
Umar Akram indicated no relevant financial relationships.
Ehsan Majeed indicated no relevant financial relationships.
Eeman Ahmad, MBBS1, Shahzaib Ahmed, MBBS1, Shamsa M. Qaadri, BSc2, Iyad Al-bustami, MD, MPH(c)3, Abbas H.. Mallick, MD4, Umar Akram, 5, Ehsan Majeed, MBBS1. P4937 - Trends and Disparities in Peritonitis-Related Mortality in the United States Over Two Decades: Insights From the CDC WONDER Database, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.
