P5044 - Racial/Ethnic Disparities in Gastric Cancer Incidence and Mortality Among Individuals Aged 50 Years and Above: A Population-Based Analysis

Bibek Karki, MD, MPH¹, Michelle Bernshteyn, MD², Samjhana Belbase, MD¹, Murtaza Hussein, MD³, Subash Ghimire, MD², Tsujung Yang, MD², Pujan N. Kandel, MD⁴, Navindra Dhakal, MD⁵, Sanju Poudel, MD⁵, Ajit Brar, MD⁶, Calvin Ghimire, MD⁷, Pradip Chaudhary, MD¹, Neela sunuwar, MD⁸, Philip McDonald, MD¹, Matthew Lincoln, DO², Michael Georgetson, MD^2
1Hurley Medical Center, Flint, MI; ²Guthrie Robert Packer Hospital, Sayre, PA; ³Sparrow Hospital, Michigan State University, Lansing, MI; ⁴HCA Florida Citrus Memorial Hospital, Hernando, FL; ⁵KIST Medical College, Kathmandu, Gandaki, Nepal; ⁶Hurley Medical Center, Auburn Hills, MI; ⁷McLaren Flint Hospital, Flint, MI; ⁸BPKIHS, Kathmandu, Gandaki, Nepal

Introduction: Gastric cancer is one of the most common gastrointestinal cancers in the US and worldwide. The aim of our study is to analyze the incidence and incidence-based mortality of gastric cancer among individuals aged 50 years and above, focusing on racial/ethnic disparities.

Methods: We conducted a retrospective study utilizing the SEER (Surveillance, Epidemiology, and End Results) database, from 17 registries, November 2022 from 2000-2020 to identify individuals diagnosed with gastric cancer aged 50 years and above. Age adjustment was done using the 2000 US population as the standard population.

Results: A total of 114,543 patients with gastric cancer were identified, with an incidence rate of 23.0 per 100,000. The incidence rates per 100,000 patients were 35.4 for Asian/Pacific Islanders, 34.6 for Blacks, 21.0 for American Indian/Natives, and 20.4 for Whites. The incidence-based mortality rates per 100,000 were 28.8 for Blacks, 26.3 for Asian/Pacific Islanders, 18.7 for American Indians/Natives, and 16.3 for Whites.

Our study showed a decreasing temporal trend of incidence with an average annual percentage change (AAPC) for all ethnicities, with the most significant decrease observed among the Asian/Pacific Islanders (-3.5, 95% CI: -3.9 to -3.0), and the lowest decrease note among the White population (-1.4, 95% CI: -1.7 to -1.2). The incidence-based mortality showed an increased temporal trend for all races from 2000 to 2002, after which it started to decline, particularly among Asian/Pacific Islanders. The incidence-based mortality was highest among Black individuals, followed by Asian/Pacific Islanders, and American Indian/Natives, and was the lowest among White individuals.

Discussion: The reduction in the incidence of gastric cancer could be due to improved H. pylori awareness and management, healthy dietary changes (less salted, or smoked foods), smoking reduction, and better access to healthcare. The incidence-based mortality started declining after 2002 likely due to early detection with public health initiatives and education, recent advancements in treatment options, and enhanced surgical techniques.

However, incidence-based mortality remains highest among certain races due to low literacy, low socioeconomic status, and unhealthy lifestyles. These findings highlight the need for targeted interventions and continuous monitoring of gastric cancer trends to address racial/ethnic disparities in cancer outcomes.



Disclosures:


Bibek Karki, MD, MPH¹, Michelle Bernshteyn, MD², Samjhana Belbase, MD¹, Murtaza Hussein, MD³, Subash Ghimire, MD², Tsujung Yang, MD², Pujan N. Kandel, MD⁴, Navindra Dhakal, MD⁵, Sanju Poudel, MD⁵, Ajit Brar, MD⁶, Calvin Ghimire, MD⁷, Pradip Chaudhary, MD¹, Neela sunuwar, MD⁸, Philip McDonald, MD¹, Matthew Lincoln, DO², Michael Georgetson, MD². P5044 - Racial/Ethnic Disparities in Gastric Cancer Incidence and Mortality Among Individuals Aged 50 Years and Above: A Population-Based Analysis, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.