P5060 - Population Characteristics of Gastric Cancer in Rhode Island, From 2014 to 2023

Sapana R. Gupta, MD¹, Naveena P. Sunkara, MD², Kanhai Farrakhan, MD³, Joao Felipe. Monteiro, PhD³, Harlan Rich, MD^1
1Brown University / Rhode Island Hospital, Providence, RI; ²Warren Alpert Medical School of Medicine, Providence, RI; ³Rhode Island Hospital, Providence, RI

Introduction: In the United States, there have been discrepancies noted in the rates of incidence of gastric cancer (GC), especially in minority populations. Here, we present preliminary data describing the population characteristics of patients diagnosed with primary gastric adenocarcinoma to better understand the risk of disease development.

Methods: This is a retrospective analysis of 240 patients diagnosed with all GC based on biopsy results, at Lifespan hospital sites in Rhode Island, from 2014 to 2023. The Latinx population was defined based on the country of origin (Latin American), and/or identified as Hispanic, and/or had primary language as Spanish. 43 patients were excluded because they did not have primary GC. We investigated how GC is distributed in the Latinx population by race, age, and smoking status. Chi-square, Fisher exact, or Student’s t-tests were performed for descriptive analyses, as appropriate. A multivariable logistic regression model was used to compare rates of GC, and adjusted by gender, age, or smoking status. The analysis was performed in SAS version 9.4.

Results: Of the 197 patients with GC that were analyzed, 60% were non-Hispanic, White, 21% Latinx, 11% non-Hispanic, Black, 4% Asian, and 4% other races. The Latinx population was younger (58.1±18.3) compared with White (75.3±11.2, p< 0.0001) and Black (67.3±11.3, p=0.0176) patients, but similar in age to Asian patients (58.3±13.3, p=0.8354). Patients over 60 years old were more likely to be non-Hispanic, White (OR 9.17[4.06-20.73]). GC patients under 60 years old were 8 times more likely to be Latinx (8.11[3.54-18.59]), and GC patients under 50 years old were more than 18x likely to be Latinx (17.71[5.74-54.699]). 100% of patients under 40 were Latinx. Of the patients studied, 45% were former smokers, 12% were current smokers, 46% never smoked, and 2% had an unknown smoking status. Patients over 60 years old were 2 times more likely to be former or current smokers (2.15[1.03-4.47]). Patients under 50 years old were over 8 times more likely to have a recurrent GC (8.44[1.46-48.73]).

Discussion: In our hospital setting, we have seen that patients with primary GC under 60 years old were predominately Latinx. Recurrence rates are significantly higher in the younger population. Smoking status appears to be a more significant risk factor in those over 60 years old. Further studies are needed to clarify the risk association with genetic and/or environmental factors to explain these differences in the younger Latinx population.


Disclosures:


Sapana R. Gupta, MD¹, Naveena P. Sunkara, MD², Kanhai Farrakhan, MD³, Joao Felipe. Monteiro, PhD³, Harlan Rich, MD¹. P5060 - Population Characteristics of Gastric Cancer in Rhode Island, From 2014 to 2023, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.