University of Mississippi Medical Center Madison, MS
Award: Presidential Poster Award
Yousaf Zafar, MD1, Muhammad Saad, 2, Muhammad Umer Sohail, 2, Syed Zaeem Ahmed, 3, Muhammad Ovais Sohail, 4, Shahryar Khan, MD5, Laila Manzoor, 1, Arsalan Zafar Iqbal, 1, Sahla Hammad, MD6 1University of Mississippi Medical Center, Madison, MS; 2Dow University of Health Sciences, Madison, MS; 3Dow University of Health Sciences, Karachi, Sindh, Pakistan; 4Conemaugh Memorial Medical Center, Karachi, Sindh, Pakistan; 5University of Kansas, Overland Park, KS; 6Atrium Health, Charlotte, NC
Introduction: Hepatitis C prevalence and mortality are reported to be higher in Oklahoma compared to other states in the United States (U.S.). This study investigates the temporal trends in Hepatitis C mortality in Oklahoma versus other U.S. states from 1999 to 2020
Methods: We utilized the Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) database to analyze Hepatitis C mortality in adults aged ≥25 years. Age-adjusted mortality rates (AAMRs) and crude mortality rates (CMRs) per 100,000 persons were calculated. Joinpoint regression was employed to assess trends and compute the average annual percent change (AAPC), with stratification by sex, age, and geographic region.
Results: In Oklahoma, the AAMR increased from 4.87 in 1999 to 15.9 in 2020 per 100,000 persons, whereas in other states, it rose from 4.45 to 5.20. The AAPC indicated a greater increase in Oklahoma from 1999 to 2020 (AAPC: 4.93 [95% CI: 4.09 to 6.42]) compared to other states (AAPC: 0.30 [95% CI: -0.06 to 0.78]). Males in Oklahoma had a higher overall AAMR (19.15) compared to males in other states (AAMR: 9.62), and females in Oklahoma also exhibited higher rates (AAMR: 8.34) compared to females in other states (AAMR: 3.7). Young adults (ages 25-44) in Oklahoma had a higher CMR (3.08) compared to young adults in other states (CMR: 1.28). Similarly, Middle-aged adults (45-64 years) in Oklahoma displayed a higher overall CMR (27.07) than those in other states (CMR: 12.31). Lastly, older adults (65+ years) in Oklahoma also exhibited a higher CMR (27.07) compared to other states (CMR: 8.7). Urban areas in Oklahoma exhibited a higher AAMR (13.86) than urban areas in other states (AAMR: 6.66), and rural areas in Oklahoma also had a higher AAMR (13.12) compared to rural areas in other states (AAMR: 5.9).
Discussion: Hepatitis C mortality rates have remained disproportionately higher in Oklahoma compared to other states. Further research is necessary to understand these disparities and develop preventive strategies to address the Hepatitis C burden in Oklahoma.
Figure: Trends in Mortality related to Hepatitis C Comparing Oklahoma with other states based on (A) Sex (B) Age groups and (C) Urbanization.
Disclosures:
Yousaf Zafar indicated no relevant financial relationships.
Muhammad Saad indicated no relevant financial relationships.
Muhammad Umer Sohail indicated no relevant financial relationships.
Syed Zaeem Ahmed indicated no relevant financial relationships.
Muhammad Ovais Sohail indicated no relevant financial relationships.
Shahryar Khan indicated no relevant financial relationships.
Laila Manzoor indicated no relevant financial relationships.
Arsalan Zafar Iqbal indicated no relevant financial relationships.
Sahla Hammad indicated no relevant financial relationships.
Yousaf Zafar, MD1, Muhammad Saad, 2, Muhammad Umer Sohail, 2, Syed Zaeem Ahmed, 3, Muhammad Ovais Sohail, 4, Shahryar Khan, MD5, Laila Manzoor, 1, Arsalan Zafar Iqbal, 1, Sahla Hammad, MD6. P4576 - Breaking Boundaries: A Comparative Study of Hepatitis C Mortality Rates in Oklahoma Against the Nation, 1999-2020, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.
