P1717 - Disparities in Acute Pancreatitis-Related Mortality Among Diabetics in the United States

M Danial Ali Shah, MD¹, Umar Hayat, MD², Saba Afroz, MD², Waqas Rasheed, MD³, Muhammad Kamal, MD⁴, Azhar Hussain, MBBS⁵, Manesh Kumar Gangwani, MD⁶, Kamran Zahoor, MD⁷, Aamir Saeed, MD⁸, Hassam Ali, MD⁹, Amna Iqbal, MD¹⁰, Dushyant S. Dahiya, MD¹¹, Faisal Kamal, MD^12
1King Edward Medical University, Lahore, Punjab, Pakistan; ²Geisinger Wyoming Valley Medical Center, Wilkes-Barre, PA; ³University of Kentucky, Lexington, KY; ⁴Hackensack Meridian Health, Roselle Park, NJ; ⁵SUNY Upstate Medical University, Syracuse, NY; ⁶University of Toledo, Toledo, OH; ⁷Allama Iqbal Medical College, Lahore, Punjab, Pakistan; ⁸Vanderbilt University Medical Center, Nashville, TN; ⁹ECU Health Medical Center, Greenville, NC; ¹⁰University of Toledo Medical Center, Toledo, OH; ¹¹The University of Kansas School of Medicine, Kansas City, KS; ¹²Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA

Introduction: Diabetes mellitus (DM) and acute pancreatitis (AP) are prevalent conditions in the United States (US). While previous studies have established an association between DM and adverse outcomes in AP, there remains a gap in understanding mortality disparities and trends within this context. This study seeks to uncover these disparities and provide insights crucial for shaping future healthcare strategies to reduce mortality among this demographic.

Methods: We performed a retrospective analysis using the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) database, using ICD-10 codes (K85, E10-14) among diabetic individuals aged 15 and older who died with AP from 1999 to 2020. Results were stratified by age, gender, race, region, rural/urban classification, and place of death, reported as age-adjusted mortality rates (AAMR) with 95% confidence intervals (CI). Joinpoint regression calculated trends over time and average annual percentage change (AAPC).

Results: From 1999 to 2020, a total of 15,107 with DM died due to AP, resulting in an AAMR of 0.3 per 100,000 (95% CI: 0.3-0.3). The AAMR demonstrated a declining trend from 1999 to 2018, followed by an increase from 2018 to 2020 (AAPC -0.65; 95% CI: -2.52 to 0.4) Figure 1A &B. Male patients exhibited a higher AAMR than females (0.3 vs. 0.2). Meanwhile, Black individuals had twice the AAMR of White individuals (0.5 vs. 0.2). Geographically, the West and South regions showed the highest AAMR at 0.3 each. Among states, Oklahoma and West Virginia had the highest AAMR (0.6 and 0.5), whereas North Dakota reported the lowest (0.2). Rural areas displayed a higher AAMR than urban areas (0.3 vs. 0.2). Most deaths occurred in inpatient settings (65%), with individuals aged 65–74 years comprising the most significant proportion (20.9%) of fatalities.

Discussion: Our nationwide analysis revealed significant disparities in AP-related mortality among diabetic populations in the US. Mortality rates are consistently increasing across genders and racial groups. This emphasizes the need for policy adjustments to support high-risk individuals and enhance access to preventive and therapeutic interventions. Further research is imperative to uncover underlying factors to facilitate the development of effective preventive strategies.



Disclosures:


M Danial Ali Shah, MD¹, Umar Hayat, MD², Saba Afroz, MD², Waqas Rasheed, MD³, Muhammad Kamal, MD⁴, Azhar Hussain, MBBS⁵, Manesh Kumar Gangwani, MD⁶, Kamran Zahoor, MD⁷, Aamir Saeed, MD⁸, Hassam Ali, MD⁹, Amna Iqbal, MD¹⁰, Dushyant S. Dahiya, MD¹¹, Faisal Kamal, MD¹². P1717 - Disparities in Acute Pancreatitis-Related Mortality Among Diabetics in the United States, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.