P0402 - Colon Cancer Mortality Trends and Racial Disparities in the United States and Texas (1999-2020): CDC WONDER Data Insights

Sidra Naz, MD, MPH¹, Mazen Alasadi, MD^2
1University of Texas MD Anderson Cancer Center, Houston, TX; ²The University of Texas MD Anderson Cancer Center, Houston, TX

Introduction: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths globally and the fourth most frequently diagnosed cancer in the United States. This study aims to assess the annual trends of colon cancer-related mortality in the US and Texas and identify associated sociodemographic factors from 1999 to 2020 to assess public health efforts and shape prevention and treatment strategies.



Methods: We analyzed death certificates from the Centres for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research database (CDC's WONDER) for colon cancer mortality (ICD-10 code C18.9) in adults aged ≥25 from 1999 to 2020. Age-adjusted mortality rates (AAMRs) per 100,000 and annual percent change (APC) were calculated and stratified by year, sex, and race/ethnicity.

Results: The AAMR for colon cancer-related mortality decreased in the US from AR in 1999 to 6.3 in 2020 (APC: -3.07%; 95% CI: -2.91% to -3.21%), and in Texas from 6.8 in 1999 to 5.5 in 2020 (APC: -2.54%; 95% CI: -2.37% to -2.75%). The AAMR in US women decreased from 26.6 in 1999 to 13.9 in 2020 (APC: -3.24%; 95% CI: -3.09% to -3.38%). The AAMR in the US men decreased from 38.6 in 1999 to 21.1 in 2017 (APC: -3.42%; 95% CI: -3.31% to -3.94%) after which it decreased further to 19.8 in 2020 (APC: -2.31%; 95% CI: -0.91% to -3.32%). Non-Hispanic (NH) Black or African American (AA) population had the greatest AAMR (22.7), followed by NH American Indian or Alaska Native (17.4) and NH White (16.4) adults. The low-risk population was Hispanic or Latino with AAMR (13.7) and Asian or Pacific Islander (11.2).



Discussion: Mortality related to colon cancer has declined both in the US and in Texas over the past decade particularly in women more than men. But NH Black or AA followed by American Indian or Alaska Native and White, are at more risk than Hispanic or Latino and Asian or Pacific Islander.



Disclosures:


Sidra Naz, MD, MPH¹, Mazen Alasadi, MD². P0402 - Colon Cancer Mortality Trends and Racial Disparities in the United States and Texas (1999-2020): CDC WONDER Data Insights, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.