P0426 - Unequal Burden: Sex and Racial Disparities in Colon Cancer Mortality Across Anatomical Sites in the United States

Hassam Ali, MD¹, Alina Sehar, MD², Shiza sarfraz, MD¹, Waqas Rasheed, MD³, Umar Hayat, MD⁴, Dushyant S. Dahiya, MD⁵, Amna Iqbal, MD⁶, Sheena shamoon, MD⁷, Manesh Kumar Gangwani, MD⁸, Douglas Adler, MD^9
1East Carolina University Brody School of Medicine, Greenville, NC; ²University of Alabama at Birmingham Heersink School of Medicine, Huntsville, AL; ³University of Kentucky, Lexington, KY; ⁴Geisinger Wyoming Valley Medical Center, Wilkes-Barre, PA; ⁵The University of Kansas School of Medicine, Kansas City, KS; ⁶University of Toledo Medical Center, Toledo, OH; ⁷Rawalpindini Medical College, Lahore, Punjab, Pakistan; ⁸University of Toledo, Toledo, OH; ⁹Center for Advanced Therapeutic (CATE), Centura Health, Porter Adventist Hospital, Peak Gastroenterology, Denver, CO

Introduction: This study aims to analyze the mortality frequency due to colon cancer at different anatomical locations, stratified by sex and race in the United States. Understanding these differences can aid in targeted screening and interventions.

Methods: Data from the CDC WONDER database (1999-2020) on age-adjusted mortality rates for various colon cancer locations was analyzed and stratified by sex and race. Total deaths and percentages for each cancer location were calculated. Bar graphs were created using Python’s Matplotlib library. Patients were excluded if no location was reported for colon cancer origination (n=915,424).

Results: The total number of deaths across all given locations combined was 41,758 for colon cancer, with the highest frequency in the appendix (28.67%), followed by the sigmoid colon (24.87%), cecal (21.91%), right colon (16.72%), left colon (3.97%), and mid colon (3.87%) (Figure 1).

Males had a higher frequency of mortality from the left colon (4.41% vs. 3.58%) and sigmoid colon (28.81% vs. 21.38%) than females. Females had a higher frequency of mortality from the appendix (30.15% vs. 26.99%), cecal (24.18% vs. 19.34%), mid colon (3.95% vs. 3.78%), and right colon (16.75% vs. 16.67%) than males.

American Indian or Alaska Native individuals had the highest frequency of mortality from the sigmoid (37.37%) and cecal (25.25%) regions. Asian or Pacific Islander individuals had a higher frequency of mortality from the left colon (7.33% vs. 3.70% in White, 4.98% in Black or African American) and mid colon (3.73% vs. 3.89% in White, 3.82% in Black or African American). Black or African American individuals had a higher frequency of mortality from the cecal (23.84% vs. 22.08% in White, 11.47% in Asian or Pacific Islander, and 25.25% in American Indian or Alaska Native) and appendix (28.67% vs. 28.96% in White, 22.73% in Asian or Pacific Islander, and 22.22% in American Indian or Alaska Native) regions. White individuals had the highest frequency of mortality from the appendix (28.96%), right colon (16.69%), and sigmoid (24.68%) regions compared to other races.

Discussion: The study highlights significant disparities in mortality rates by sex and race for various colon cancer locations in the United States. Females had higher mortality rates in the appendix, cecal, mid colon, and right colon regions, while males had higher rates in the left colon and sigmoid regions. These findings underscore the need for further research into the underlying causes of these disparities.



Disclosures:


Hassam Ali, MD¹, Alina Sehar, MD², Shiza sarfraz, MD¹, Waqas Rasheed, MD³, Umar Hayat, MD⁴, Dushyant S. Dahiya, MD⁵, Amna Iqbal, MD⁶, Sheena shamoon, MD⁷, Manesh Kumar Gangwani, MD⁸, Douglas Adler, MD⁹. P0426 - Unequal Burden: Sex and Racial Disparities in Colon Cancer Mortality Across Anatomical Sites in the United States, ACG 2024 Annual Scientific Meeting Abstracts. Philadelphia, PA: American College of Gastroenterology.